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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kitchen, S. G. Articles by Zack, J. A. Search for Related Content PubMed PubMed Citation Articles by Kitchen, S. G. Articles by Zack, J. A. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2002, Vol. 99, No. 1, pp. 207-212 IMMUNOBIOLOGY Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor Scott G. Kitchen, Stuart LaForge, Viresh P. Patel, Christina M. Kitchen, M. Carrie Miceli, and Jerome A. Zack From the Department of Medicine and the University of California, Los Angeles (UCLA) AIDS Institute; the Departments of Microbiology, Immunology, and Molecular Genetics and the Molecular Biology Institute, UCLA School of Medicine; and the Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA. It was previously shown that costimulation of CD8+ lymphocytes results in de novo expression of CD4. This study expanded on this observation to investigate the function of CD4 on CD8 cells. The ability of costimulated CD8 cells to respond to interleukin 16 (IL-16), a ligand that binds CD4 and induces cellular chemotaxis, was examined. IL-16-mediated ligation of CD4 expressed on CD8 T cells was found to induce an intracellular signal that directs migration of these cells in vitro. Thus, expression of CD4 on a CD8 lymphocyte has functional importance and may serve to control distribution of newly activated CD8 T cells in vivo. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Zloza, J. M. Schenkel, A. R. Tenorio, J. A. Martinson, P. M. Jeziorczak, and L. Al-Harthi Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface Blood, October 29, 2009; 114(18): 3841 - 3853. [Abstract] [Full Text] [PDF] H. B. Bernstein, M. C. Plasterer, S. E. Schiff, C. M. R. Kitchen, S. Kitchen, and J. A. Zack CD4 Expression on Activated NK Cells: Ligation of CD4 Induces Cytokine Expression and Cell Migration J. Immunol., September 15, 2006; 177(6): 3669 - 3676. [Abstract] [Full Text] [PDF] A. Zloza and L. Al-Harthi Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration J. Leukoc. Biol., January 1, 2006; 79(1): 4 - 6. [Full Text] [PDF] S. G. Kitchen, J. K. Whitmire, N. R. Jones, Z. Galic, C. M. R. Kitchen, R. Ahmed, and J. A. Zack The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens PNAS, March 8, 2005; 102(10): 3794 - 3799. [Abstract] [Full Text] [PDF] V. Monsurro, E. Wang, Y. Yamano, S. A. Migueles, M. C. Panelli, K. Smith, D. Nagorsen, M. Connors, S. Jacobson, and F. M. Marincola Quiescent phenotype of tumor-specific CD8+ T cells following immunization Blood, October 1, 2004; 104(7): 1970 - 1978. [Abstract] [Full Text] [PDF] A. Cochrane, S. Imlach, C. Leen, G. Scott, D. Kennedy, and P. Simmonds High Levels of Human Immunodeficiency Virus Infection of CD8 Lymphocytes Expressing CD4 In Vivo J. Virol., September 15, 2004; 78(18): 9862 - 9871. 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