|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 January 2002, Vol. 99, No. 1, pp. 3-9
PLENARY PAPER
Gastric marginal zone B-cell lymphomas of MALT type develop
along 2 distinct pathogenetic pathways
Petr Starostik,
Jochen Patzner,
Axel Greiner,
Stephan Schwarz,
Jörg Kalla,
German Ott, and
Hans Konrad Müller-Hermelink
From the Institute of Pathology, Würzburg
University, Germany.
Low-grade marginal zone B-cell lymphoma of mucosa-associated
lymphoid tissue (MALT) type can transform into high-grade diffuse large
B-cell lymphoma (DLBCL). Up to 60% of the MALT lymphomas contain the
recently described t(11;18). However, this translocation has
not been detected in any DLBCL so far. To elucidate the pathogenesis of
these tumors, microsatellite screening of 24 gastric MALT lymphomas was
performed and the results were compared with aberrations detected in a
previous study on gastric DLBCL. The most frequent aberration, found in
21% of the MALT lymphomas that were exclusively t(11;18)-negative cases, was amplification of the 3q26.2-27 region (harboring the locus
of the BCL6 gene). Allelic imbalances in regions 3q26.2-27, 6q23.3-25, 7q31, 11q23-24, and 18q21 were shared by both MALT lymphoma
and DLBCL. Loss of heterozygosity in regions 5q21 (APC gene
locus), 9p21 (INK4A/ARF), 13q14 (RB), and 17p13
(p53) and allelic imbalances in 2p16, 6p23, and 12p12-13
occurred exclusively in DLBCL. Only one of 10 t(11;18)-positive
MALT lymphomas showed an additional clonal abnormality. These tumors
thus display features of a clonal proliferation characterized by the
presence of the t(11;18). However, they only rarely display secondary
aberrations and do not seem to transform into DLBCL. In contrast,
t(11;18)-negative MALT lymphomas show numerous allelic imbalances some
of them identical with aberrations seen in DLBCLsuggesting that this
group is the source of tumors eventually transforming into high-grade DLBCL.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
Pathogenic complexity of gastric B-cell lymphoma
- Thomas F. E. Barth, Martin Bentz, Frank Leithäuser, Stephan Stilgenbauer, Reiner Siebert, Magdalena Schlotter, Richard F. Schlenk, Hartmut Döhner, Peter Möller, Petr Starostik, Axel Greiner, Jörg Kalla, Andreas Zettl, and Hans Konrad Müller-Hermelink
Blood 2002 100: 1095-1097.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
R. J. Bende, F. van Maldegem, and C. J.M. van Noesel
Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas
Haematologica,
August 1, 2009;
94(8):
1109 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M Bacon, M.-Q. Du, and A. Dogan
Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists
J. Clin. Pathol.,
April 1, 2007;
60(4):
361 - 372.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Cohen, M. Petryk, M. Varma, P. S. Kozuch, E. D. Ames, and M. L. Grossbard
Non-Hodgkin's Lymphoma of Mucosa-Associated Lymphoid Tissue
Oncologist,
November 1, 2006;
11(10):
1100 - 1117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L D Sjo, E Ralfkiaer, B R Juhl, J U Prause, T Kivela, C Auw-Haedrich, F Bacin, M Carrera, S E Coupland, B Delbosc, et al.
Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study
Br J Ophthalmol,
August 1, 2006;
90(8):
1004 - 1009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Hummel, S Oeschger, T F E Barth, C Loddenkemper, S B Cogliatti, A Marx, H-H Wacker, A C Feller, H-W Bernd, M-L Hansmann, et al.
Wotherspoon criteria combined with B cell clonality analysis by advanced polymerase chain reaction technology discriminates covert gastric marginal zone lymphoma from chronic gastritis
Gut,
June 1, 2006;
55(6):
782 - 787.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Wundisch, C. Thiede, A. Morgner, A. Dempfle, A. Gunther, H. Liu, H. Ye, M.-Q. Du, T. D. Kim, E. Bayerdorffer, et al.
Long-Term Follow-Up of Gastric MALT Lymphoma After Helicobacter Pylori Eradication
J. Clin. Oncol.,
November 1, 2005;
23(31):
8018 - 8024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Farinha and R. D. Gascoyne
Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6370 - 6378.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B.Y. Hui, H. Takano, K.-W. Lo, W.-L. Kuo, C. N.Y. Lam, C. Y.K. Tong, Q. Chang, J. W. Gray, and H.-K. Ng
Identification of a Novel Homozygous Deletion Region at 6q23.1 in Medulloblastomas Using High-Resolution Array Comparative Genomic Hybridization Analysis
Clin. Cancer Res.,
July 1, 2005;
11(13):
4707 - 4716.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Freedman
Biology and Management of Histologic Transformation of Indolent Lymphoma
Hematology,
January 1, 2005;
2005(1):
314 - 320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Bendandi, S. A. Pileri, and P. L. Zinzani
Challenging paradigms in lymphoma treatment
Ann. Onc.,
May 1, 2004;
15(5):
703 - 711.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J Krugmann, A Tzankov, S Dirnhofer, F Fend, R Greil, R Siebert, and M Erdel
Unfavourable prognosis of patients with trisomy 18q21 detected by fluorescence in situ hybridisation in t(11;18) negative, surgically resected, gastrointestinal B cell lymphomas
J. Clin. Pathol.,
April 1, 2004;
57(4):
360 - 364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Pileri, P. L. Zinzani, P. Went, A. Pileri Jr, and M. Bendandi
Indolent lymphoma: the pathologist's viewpoint
Ann. Onc.,
January 1, 2004;
15(1):
12 - 18.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W Fischbach, M-E Goebeler-Kolve, B Dragosics, A Greiner, and M Stolte
Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series
Gut,
January 1, 2004;
53(1):
34 - 37.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. W. Tsang, M. K. Gospodarowicz, M. Pintilie, W. Wells, D. C. Hodgson, A. Sun, M. Crump, and B. J. Patterson
Localized Mucosa-Associated Lymphoid Tissue Lymphoma Treated With Radiation Therapy Has Excellent Clinical Outcome
J. Clin. Oncol.,
November 15, 2003;
21(22):
4157 - 4164.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y Kaneko, S Sakurai, M Hironaka, S Sato, S Oguni, Y Sakuma, K Sato, K Sugano, and K Saito
Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas
Gut,
May 1, 2003;
52(5):
641 - 646.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
M. Okabe, H. Inagaki, K. Ohshima, T. Yoshino, C. Li, T. Eimoto, R. Ueda, and S. Nakamura
API2-MALT1 Fusion Defines a Distinctive Clinicopathologic Subtype in Pulmonary Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
Am. J. Pathol.,
April 1, 2003;
162(4):
1113 - 1122.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Streubel, A. Lamprecht, J. Dierlamm, L. Cerroni, M. Stolte, G. Ott, M. Raderer, and A. Chott
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma
Blood,
March 15, 2003;
101(6):
2335 - 2339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Nakamura, T Matsumoto, S Nakamura, Y Jo, K Fujisawa, H Suekane, T Yao, M Tsuneyoshi, and M Iida
Chromosomal translocation t(11;18)(q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma
J. Clin. Pathol.,
January 1, 2003;
56(1):
36 - 42.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. F. E. Barth, M. Bentz, F. Leithauser, S. Stilgenbauer, R. Siebert, M. Schlotter, R. F. Schlenk, H. Dohner, P. Moller, P. Starostik, et al.
Pathogenic complexity of gastric B-cell lymphoma
Blood,
August 1, 2002;
100(3):
1095 - 1097.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Remstein, P. J. Kurtin, C. D. James, X.-Y. Wang, R. G. Meyer, and G. W. Dewald
Mucosa-Associated Lymphoid Tissue Lymphomas with t(11;18)(q21;q21) and Mucosa-Associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways
Am. J. Pathol.,
July 1, 2002;
161(1):
63 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Biagi and J. F. Seymour
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation
Blood,
May 29, 2002;
99(12):
4265 - 4275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
