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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Morison, I. M. Articles by Reeve, A. E. Search for Related Content PubMed PubMed Citation Articles by Morison, I. M. Articles by Reeve, A. E. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2002, Vol. 99, No. 1, pp. 375-377 BRIEF REPORT Preferential loss of maternal 9p alleles in childhood acute lymphoblastic leukemia Ian M. Morison, Lana M. Ellis, Lochie R. Teague, and Anthony E. Reeve From the Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand; and Paediatric Haematology/Oncology, Starship Children's Health, Auckland, New Zealand. Germ-line events, such as paternal mutation or genomic imprinting, contribute to the early onset of childhood cancers such as retinoblastoma, Wilms tumors, and neuroblastoma. Given the high frequency of deletion involving chromosome 9p in childhood acute lymphoblastic leukemia (ALL), this study investigated whether 9p deletion might reflect preexisting germ-line gene inactivation. To do this the parental origin of deletion was determined in 10 cases of ALL with 9p21 loss of heterozygosity. Of these cases, 9 showed loss of the maternally derived allele, suggesting that a germ-line event involving a 9p gene may play a role in the onset of childhood ALL. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. L. Wilson, I. M. Morison, K. Paulsson, and B. Johansson No evidence for preferential maternal origin of duplicated chromosome 14 in hyperdiploid ALL Blood, February 15, 2005; 105(4): 1837 - 1838. [Full Text] [PDF] M. Raghavan, D. M. Lillington, S. Skoulakis, S. Debernardi, T. Chaplin, N. J. Foot, T. A. Lister, and B. D. Young Genome-Wide Single Nucleotide Polymorphism Analysis Reveals Frequent Partial Uniparental Disomy Due to Somatic Recombination in Acute Myeloid Leukemias Cancer Res., January 15, 2005; 65(2): 375 - 378. [Abstract] [Full Text] [PDF] K. Paulsson, I. Panagopoulos, S. Knuutila, K. J. Jee, S. Garwicz, T. Fioretos, F. Mitelman, and B. Johansson Formation of trisomies and their parental origin in hyperdiploid childhood acute lymphoblastic leukemia Blood, October 15, 2003; 102(8): 3010 - 3015. [Abstract] [Full Text] [PDF] C. J. M. van Schooten, L. M. Ellis, I. M. Morison, and J. Webb Reassessment of loss of heterozygosity within MLL in childhood acute lymphoblastic leukemia Blood, May 15, 2003; 101(10): 4222 - 4222. [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020