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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Abe, M. Articles by Yang, Y.-G. Search for Related Content PubMed PubMed Citation Articles by Abe, M. Articles by Yang, Y.-G. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2002, Vol. 99, No. 10, pp. 3823-3829 TRANSPLANTATION Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier Masahiro Abe, Jin Qi, Megan Sykes, and Yong-Guang Yang From the Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA. Induction of tolerance is likely to be essential for successful xenotransplantation because immune responses across xenogeneic barriers are vigorous. Although mixed hematopoietic chimerism leads to stable donor-specific tolerance in allogeneic and closely related xenogeneic (eg, rat-to-mouse) combinations, the ability of this approach to induce tolerance across a highly disparate xenogeneic barrier has not yet been demonstrated. In this study, we investigated the immune responses of murine T cells that developed in mice with pre-established porcine hematopoietic chimerism. Our results show for the first time that induction of porcine hematopoietic chimerism can eliminate the development of antiporcine donor responses in a highly disparate xenogeneic species. Porcine hematopoietic chimeras showed donor-specific nonresponsiveness in the mixed lymphocyte reaction, lack of antidonor IgG antibody production, and acceptance of donor skin grafts. Thus, mixed chimerism is capable of inducing tolerance in a highly disparate xenogeneic combination and may have clinical potential to prevent xenograft rejection. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Li, Y. Yan, Y. Lin, D. M. Bullens, O. Rutgeerts, J. Goebels, C. Segers, L. Boon, A. Kasran, R. De Vos, et al. Rapidly induced, T-cell independent xenoantibody production is mediated by marginal zone B cells and requires help from NK cells Blood, December 1, 2007; 110(12): 3926 - 3935. [Abstract] [Full Text] [PDF] H. Wang, J. VerHalen, M. L. Madariaga, S. Xiang, S. Wang, P. Lan, P.-A. Oldenborg, M. Sykes, and Y.-G. Yang Attenuation of phagocytosis of xenogeneic cells by manipulating CD47 Blood, January 15, 2007; 109(2): 836 - 842. [Abstract] [Full Text] [PDF] A. S. Narang and R. I. Mahato Biological and biomaterial approaches for improved islet transplantation. Pharmacol. Rev., June 1, 2006; 58(2): 194 - 243. [Abstract] [Full Text] [PDF] P. Lan, L. Wang, B. Diouf, H. Eguchi, H. Su, R. Bronson, D. H. Sachs, M. Sykes, and Y.-G. Yang Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism Blood, May 15, 2004; 103(10): 3964 - 3969. [Abstract] [Full Text] [PDF] M D Dooldeniya and A N Warrens Xenotransplantation: where are we today? J R Soc Med, March 1, 2003; 96(3): 111 - 117. [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020