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Blood, 15 May 2002, Vol. 99, No. 10, pp. 3844-3847

BRIEF REPORT

Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles

David M. Koelle, Hongbo B. Chen, Christopher M. McClurkan, and Effie W. Petersdorf

From the Departments of Medicine, Laboratory Medicine, and Pathobiology, University of Washington, Seattle; the Virginia Mason Research Center, Seattle, WA; and the Fred Hutchinson Cancer Research Center, Seattle, WA

Clonally expressed T-cell receptor alpha beta heterodimers are able to bind many different major histocompatibility complex/peptide combinations. This promiscuity is thought to be required for adequate surveillance against microbial and malignancy-associated antigens. After transplantation, T cells may react with nonself structures, contributing to graft-versus-host disease, in the case of hematopoietic stem cell transplantation, or graft failure, when the host immune system is preserved. We describe 2 distinct HLA A*0201-restricted, cytotoxic CD8 T-cell responses to the prevalent chronic pathogen, herpes simplex virus type 2, that cross-react with cells bearing specific alleles of the common HLA B44 family. Transfection of human or primate renal epithelial cells with HLA class I complementary DNA confirmed these results. Given the prevalence of this viral infection and the HLA alleles involved, it is possible that this cross-reactivity may be involved in clinically significant events.

© 2002 by The American Society of Hematology.
 

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