|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 June 2002, Vol. 99, No. 12, pp. 4554-4561
NEOPLASIA
Evidence for distinct pathomechanisms in B-cell chronic
lymphocytic leukemia and mantle cell lymphoma by quantitative
expression analysis of cell cycle and apoptosis-associated
genes
Christian Korz,
Armin Pscherer,
Axel Benner,
Daniel Mertens,
Claudia Schaffner,
Elke Leupolt,
Hartmut Döhner,
Stephan Stilgenbauer, and
Peter Lichter
From Abteilung Molekulare Genetik and Zentrale Einheit
Biostatistik, Deutsches Krebsforschungszentrum, Heidelberg, and
Abteilung Innere Medizin III, Universität Ulm, Germany.
The B-cell lymphoproliferative malignancies B-cell chronic
lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) share characteristics, including overlapping chromosomal aberrations with
deletions on chromosome bands 13q14, 11q23, 17p13, and 6q21 and gains
on chromosome bands 3q26, 12q13, and 8q24. To elucidate the biochemical
processes involved in the pathogenesis of B-CLL and MCL, we analyzed
the expression level of a set of genes that play central roles in
apoptotic or cell proliferation pathways and of candidate genes from
frequently altered genomic regions, namely ATM, BAX,
BCL2, CCND1, CCND3, CDK2,
CDK4, CDKN1A, CDKN1B, E2F1, ETV5, MYC, RB1,
SELL, TFDP2, TNFSF10, and
TP53. Performing real-time quantitative reverse transcription
polymerase chain reaction in a panel of patients with MCL and B-CLL and
control samples, significant overexpression and underexpression was
observed for most of these genes. Statistical analysis of the
expression data revealed the combination of CCND1 and CDK4 as the best
classifier concerning separation of both lymphoma types. Overexpression
in these malignancies suggests ETV5 as a new candidate for a pathogenic factor in B-cell lymphomas. Characteristic deregulation of multiple genes analyzed in this study could be combined in a comprehensive picture of 2 distinctive pathomechanisms in B-CLL and MCL. In B-CLL,
the expression parameters are in strong favor of protection of the
malignant cells from apoptosis but did not provide evidence for
promoting cell cycle. In contrast, in MCL the impairment of apoptosis
induction seems to play a minor role, whereas most expression data
indicate an enhancement of cell proliferation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. S. Boyd, R. Jukes-Jones, R. Walewska, D. Brown, M. J. S. Dyer, and K. Cain
Protein Profiling of Plasma Membranes Defines Aberrant Signaling Pathways in Mantle Cell Lymphoma
Mol. Cell. Proteomics,
July 1, 2009;
8(7):
1501 - 1515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Hu and B. J. Barnes
IRF-5 Is a Mediator of the Death Receptor-induced Apoptotic Signaling Pathway
J. Biol. Chem.,
January 30, 2009;
284(5):
2767 - 2777.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Oliere, M. Arguello, T. Mesplede, V. Tumilasci, P. Nakhaei, D. Stojdl, N. Sonenberg, J. Bell, and J. Hiscott
Vesicular Stomatitis Virus Oncolysis of T Lymphocytes Requires Cell Cycle Entry and Translation Initiation
J. Virol.,
June 15, 2008;
82(12):
5735 - 5749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sander, L. Bullinger, E. Leupolt, A. Benner, D. Kienle, T. Katzenberger, J. Kalla, G. Ott, H. K. Muller-Hermelink, T. F.E. Barth, et al.
Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations
Haematologica,
May 1, 2008;
93(5):
680 - 687.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Kienle, A. Benner, A. Krober, D. Winkler, D. Mertens, A. Buhler, T. Seiler, U. Jager, P. Lichter, H. Dohner, et al.
Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes
Blood,
March 1, 2006;
107(5):
2090 - 2093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. A. Calin, M. Ferracin, A. Cimmino, G. Di Leva, M. Shimizu, S. E. Wojcik, M. V. Iorio, R. Visone, N. I. Sever, M. Fabbri, et al.
A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia
N. Engl. J. Med.,
October 27, 2005;
353(17):
1793 - 1801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. V. Abruzzo, J. Wang, M. Kapoor, L. J. Medeiros, M. J. Keating, W. E. Highsmith, L. L. Barron, C. C. Cromwell, and K. R. Coombes
Biological Validation of Differentially Expressed Genes in Chronic Lymphocytic Leukemia Identified by Applying Multiple Statistical Methods to Oligonucleotide Microarrays
J. Mol. Diagn.,
August 1, 2005;
7(3):
337 - 345.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Lacrima, A. Valentini, C. Lambertini, M. Taborelli, A. Rinaldi, E. Zucca, C. Catapano, F. Cavalli, A. Gianella-Borradori, D. E. MacCallum, et al.
In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
Ann. Onc.,
July 1, 2005;
16(7):
1169 - 1176.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Kienle, C. Korz, B. Hosch, A. Benner, D. Mertens, A. Habermann, A. Krober, U. Jager, P. Lichter, H. Dohner, et al.
Evidence for Distinct Pathomechanisms in Genetic Subgroups of Chronic Lymphocytic Leukemia Revealed by Quantitative Expression Analysis of Cell Cycle, Activation, and Apoptosis-Associated Genes
J. Clin. Oncol.,
June 1, 2005;
23(16):
3780 - 3792.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Hernandez, S. Bea, M. Pinyol, G. Ott, T. Katzenberger, A. Rosenwald, F. Bosch, A. Lopez-Guillermo, J. Delabie, D. Colomer, et al.
CDK4 and MDM2 Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-type INK4a/ARF Locus
Cancer Res.,
March 15, 2005;
65(6):
2199 - 2206.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Fischer, M. Skowron, and F. Berthold
Reliable Transcript Quantification by Real-Time Reverse Transcriptase-Polymerase Chain Reaction in Primary Neuroblastoma Using Normalization to Averaged Expression Levels of the Control Genes HPRT1 and SDHA
J. Mol. Diagn.,
February 1, 2005;
7(1):
89 - 96.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Cario, M. Stanulla, B. M. Fine, O. Teuffel, N. v. Neuhoff, A. Schrauder, T. Flohr, B. W. Schafer, C. R. Bartram, K. Welte, et al.
Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia
Blood,
January 15, 2005;
105(2):
821 - 826.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Atayar, S. Poppema, T. Blokzijl, G. Harms, M. Boot, and A. van den Berg
Expression of the T-Cell Transcription Factors, GATA-3 and T-bet, in the Neoplastic Cells of Hodgkin Lymphomas
Am. J. Pathol.,
January 1, 2005;
166(1):
127 - 134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rodriguez, N. Martinez, F. I. Camacho, E. Ruiz-Ballesteros, P. Algara, J.-F. Garcia, J. Menarguez, T. Alvaro, M. F. Fresno, F. Solano, et al.
Variability in the Degree of Expression of Phosphorylated I{kappa}B{alpha} in Chronic Lymphocytic Leukemia Cases With Nodal Involvement
Clin. Cancer Res.,
October 15, 2004;
10(20):
6796 - 6806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Debacq, B. Asquith, M. Reichert, A. Burny, R. Kettmann, and L. Willems
Reduced Cell Turnover in Bovine Leukemia Virus-Infected, Persistently Lymphocytotic Cattle
J. Virol.,
December 15, 2003;
77(24):
13073 - 13083.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Korshunov, K. Neben, G. Wrobel, B. Tews, A. Benner, M. Hahn, A. Golanov, and P. Lichter
Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age
Am. J. Pathol.,
November 1, 2003;
163(5):
1721 - 1727.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Wahl, E. Nossner, K. Kronenberger, R. Gangnus, H. Pohla, M. S. Staege, H.-J. Kolb, M. Hallek, and R. Mocikat
Vaccination against B-cell Chronic Lymphocytic Leukemia with Trioma Cells: Preclinical Evaluation
Clin. Cancer Res.,
September 15, 2003;
9(11):
4240 - 4246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Y. Fang, T. C. Greiner, D. D. Weisenburger, W. C. Chan, J. M. Vose, L. M. Smith, J. O. Armitage, R. A. Mayer, B. L. Pike, F. S. Collins, et al.
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma
PNAS,
April 29, 2003;
100(9):
5372 - 5377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
