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Related Collections Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2002, Vol. 99, No. 2, pp. 427-436 CHEMOKINES Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant Karl Balabanian, Arnaud Foussat, Laurence Bouchet-Delbos, Jacques Couderc, Roman Krzysiek, Ali Amara, Françoise Baleux, Alain Portier, Pierre Galanaud, and Dominique Emilie From INSERM U131, Institut Paris-Sud sur les Cytokines, Clamart, France; and Unité d'Immunologie Virale and Unité de Chimie Organique, Institut Pasteur, Paris, France. Interleukin-10 (IL-10) is constitutively produced by peritoneal B1a lymphocytes, and stromal cell-derived factor-1 (SDF-1) by mesothelial cells. Independent studies have shown that both IL-10 and SDF-1 are involved in the persistence of the peritoneal B-lymphocyte compartment. This study shows that IL-10 and SDF-1 act in synergy on peritoneal B lymphocytes. Indeed, autocrine production of IL-10 was absolutely required for all effects of SDF-1 on these cells, including increased proliferation, survival, and chemotaxis. Moreover, adding IL-10 to peritoneal B lymphocytes increased the effects of SDF-1. Neither IL-5, IL-6, nor IL-9 affected the response of peritoneal B lymphocytes to SDF-1. IL-10 was chemokinetic for peritoneal B lymphocytes, increasing their random mobility. It also potentiated the SDF-1-induced reorganization of the cytoskeleton without affecting CXCR4 gene expression by peritoneal B lymphocytes. Despite its chemokinetic properties, IL-10 abolished the migration of peritoneal B lymphocytes in response to B-lymphocyte chemoattractant (BLC), a chemokine targeting B lymphocytes to lymphoid organ follicles. The ability of B1a lymphocytes to produce IL-10 constitutively, combined with the opposite effects of this cytokine on the responses to SDF-1 and BLC, may account for the selective accumulation of B1 lymphocytes in body cavities. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. L Oliveira, R. Chammas, L. Ricon, M. L Fermino, E. S Bernardes, D. K Hsu, F.-T. Liu, R. Borojevic, and M. C El-Cheikh Galectin-3 regulates peritoneal B1-cell differentiation into plasma cells Glycobiology, November 1, 2009; 19(11): 1248 - 1258. [Abstract] [Full Text] [PDF] M. Gouwy, S. Struyf, H. Verbeke, W. Put, P. Proost, G. Opdenakker, and J. Van Damme CC chemokine ligand-2 synergizes with the nonchemokine G protein-coupled receptor ligand fMLP in monocyte chemotaxis, and it cooperates with the TLR ligand LPS via induction of CXCL8 J. Leukoc. 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