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Blood, 15 January 2002, Vol. 99, No. 2, pp. 463-471
HEMATOPOIESIS
Identification of the earliest prethymic bipotent T/NK
progenitor in murine fetal liver
Iyadh Douagi,
Francesco Colucci,
James P. Di Santo, and
Ana Cumano
From the Unité du Développement des
Lymphocytes, and Unité des Cytokines et
Développement Lymphoïde, Département
d'Immunologie, Institut Pasteur, Paris, France.
This article describes the isolation of a novel cell population
(B220loc-kit+CD19 )
in the fetal liver that represents 70% of T-cell precursors in this
organ. Interestingly, these precursors showed a bipotent T-cell and
natural killer cell (NK)- restricted reconstitution potential but completely lacked B and erythromyeloid differentiation capacity both in vivo and in vitro. Moreover, not only mature T-cell receptor (TCR)  + peripheral T cells but
also TCR  + and
TCR+CD8+ intestinal epithelial
cells of extrathymic origin were generated in reconstituted mice. The
presence of this population in the fetal liver of athymic embryos
indicates its prethymic origin. The comparison of the phenotype and
differentiation potential of
B220loc-kit+CD19
fetal liver cells with those of thymic T/NK progenitors indicates that
this is the most immature common T/NK cell progenitor so far
identified. These fetal liver progenitors may represent the immediate
developmental step before thymic immigration.
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