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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Inabe, K. Articles by Kurosaki, T. Search for Related Content PubMed PubMed Citation Articles by Inabe, K. Articles by Kurosaki, T. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2002, Vol. 99, No. 2, pp. 584-589 IMMUNOBIOLOGY Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement Kazunori Inabe and Tomohiro Kurosaki From the Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan. CD19 is a coreceptor that amplifies signaling initiated by antigen cross-linking of the B-cell antigen receptor (BCR). CD19 can also signal independently of BCR coligation. This study shows that B-cell adaptor for phosphoinositide 3-kinase (BCAP), previously characterized as a substrate of the tyrosine kinases upon BCR engagement, is phosphorylated by cross-linking of CD19. Tyrosine phosphorylation of BCAP, mediated by Lyn, provides binding site(s) for phosphoinositide 3-kinase (PI3K), thereby participating in Akt activation. Thus, these results provide evidence that BCAP serves as an adaptor molecule for CD19 to activate the PI3K pathway in B cells. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. W. MacFarlane IV, T. Yamazaki, M. Fang, L. J. Sigal, T. Kurosaki, and K. S. Campbell Enhanced NK-cell development and function in BCAP-deficient mice Blood, July 1, 2008; 112(1): 131 - 140. [Abstract] [Full Text] [PDF] P. R. Cutillas, B. Geering, M. D. Waterfield, and B. Vanhaesebroeck Quantification of Gel-separated Proteins and Their Phosphorylation Sites by LC-MS Using Unlabeled Internal Standards: Analysis of Phosphoprotein Dynamics in a B Cell Lymphoma Cell Line Mol. Cell. Proteomics, August 1, 2005; 4(8): 1038 - 1051. [Abstract] [Full Text] [PDF] Y. Shao, C. Yang, C. Elly, and Y.-C. Liu Differential Regulation of the B Cell Receptor-mediated Signaling by the E3 Ubiquitin Ligase Cbl J. Biol. Chem., October 15, 2004; 279(42): 43646 - 43653. [Abstract] [Full Text] [PDF] E. Vigorito, G. Bardi, J. Glassford, E. W.-F. Lam, E. Clayton, and M. Turner Vav-Dependent and Vav-Independent Phosphatidylinositol 3-Kinase Activation in Murine B Cells Determined by the Nature of the Stimulus J. Immunol., September 1, 2004; 173(5): 3209 - 3214. [Abstract] [Full Text] [PDF] Y. Xu, S.-J. E. Beavitt, K. W. Harder, M. L. Hibbs, and D. M. Tarlinton The Activation and Subsequent Regulatory Roles of Lyn and CD19 After B Cell Receptor Ligation are Independent J. Immunol., December 15, 2002; 169(12): 6910 - 6918. [Abstract] [Full Text] [PDF] M. Fujimoto, J. C. Poe, A. B. Satterthwaite, M. I. Wahl, O. N. Witte, and T. F. Tedder Complementary Roles for CD19 and Bruton's Tyrosine Kinase in B Lymphocyte Signal Transduction J. Immunol., June 1, 2002; 168(11): 5465 - 5476. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020