|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 February 2002, Vol. 99, No. 3, pp. 746-753
PLENARY PAPER
The cytokines IL-3 and GM-CSF regulate the transcriptional
activity of retinoic acid receptors in different in vitro models of
myeloid differentiation
Barton S. Johnson,
LeMoyne Mueller,
Jutong Si, and
Steven J. Collins
From the Division of Hospital Dentistry, University of
Washington, and the Human Biology Division, Fred Hutchinson Cancer
Research Center, Seattle, WA.
The disruption of retinoic acid receptor (RAR) activity that
characterizes human acute promyelocytic leukemia (APL) is associated with a block to granulocytic differentiation indicating that RARs are
critical regulators of normal myeloid differentiation. Nevertheless, how RAR activity might be regulated in the presumably homogenous concentration of retinoids in blood and bone marrow and how these receptors might interact with specific hematopoietic cytokines to
regulate normal myeloid differentiation remain unclear. Here, using
several cytokine-dependent in vitro models of myeloid development, it
was observed that specific hematopoietic cytokines that
normally regulate myeloid lineage commitment and differentiation
(interleukin-3 and granulocyte-macrophage colony-stimulating factor)
trigger the enhancement of both ligand-dependent and ligand-independent transcriptional activity of both endogenous and exogenous (transiently transfected) RARs. This cytokine-mediated enhancement of RAR activity is not associated with any observed changes in expression of the RARs
or their respective coactivators/corepressors. These studies define a
previously unknown cytokine-RAR interaction during myelopoiesis and
suggest that RAR activation might be a critical downstream event
following interleukin-3 and granulocyte-macrophage colony-stimulating factor signaling during myeloid differentiation. This observation of
ligand-independent activation of RARs that is mediated by certain cytokines represents a new paradigm with respect to how RAR activity might be modulated during hematopoiesis and also suggests a molecular basis for the differential sensitivity of human acute myelogenous leukemia cells to retinoids.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Taschner, C. Koesters, B. Platzer, A. Jorgl, W. Ellmeier, T. Benesch, and H. Strobl
Down-regulation of RXR{alpha} expression is essential for neutrophil development from granulocyte/monocyte progenitors
Blood,
February 1, 2007;
109(3):
971 - 979.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shimizu, L. Esaki, H. Mizuno, and K. Takeda
Granulocyte macrophage colony-stimulating factor enhances retinoic acid-induced gene expression
J. Leukoc. Biol.,
October 1, 2006;
80(4):
889 - 896.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Szanto and L. Nagy
Retinoids Potentiate Peroxisome Proliferator-Activated Receptor {gamma} Action in Differentiation, Gene Expression, and Lipid Metabolic Processes in Developing Myeloid Cells
Mol. Pharmacol.,
June 1, 2005;
67(6):
1935 - 1943.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Glasow, N. Prodromou, K. Xu, M. von Lindern, and A. Zelent
Retinoids and myelomonocytic growth factors cooperatively activate RARA and induce human myeloid leukemia cell differentiation via MAP kinase pathways
Blood,
January 1, 2005;
105(1):
341 - 349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Hengesbach and K. A. Hoag
Physiological Concentrations of Retinoic Acid Favor Myeloid Dendritic Cell Development over Granulocyte Development in Cultures of Bone Marrow Cells from Mice
J. Nutr.,
October 1, 2004;
134(10):
2653 - 2659.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Maun, P. Gaines, A. Khanna-Gupta, T. Zibello, L. Enriquez, L. Goldberg, and N. Berliner
G-CSF signaling can differentiate promyelocytes expressing a defective retinoic acid receptor: evidence for divergent pathways regulating neutrophil differentiation
Blood,
March 1, 2004;
103(5):
1693 - 1701.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Moqattash and J. D. Lutton
Leukemia Cells and the Cytokine Network: Therapeutic Prospects
Experimental Biology and Medicine,
February 1, 2004;
229(2):
121 - 137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. T. Phan, D. B. Shultz, B.-T. H. Truong, T. J. Blake, A. L. Brown, T. J. Gonda, M. M. Le Beau, and S. C. Kogan
Cooperation of Cytokine Signaling with Chimeric Transcription Factors in Leukemogenesis: PML-Retinoic Acid Receptor Alpha Blocks Growth Factor-Mediated Differentiation
Mol. Cell. Biol.,
July 1, 2003;
23(13):
4573 - 4585.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Si and S. J. Collins
IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner
Blood,
December 15, 2002;
100(13):
4401 - 4409.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-C. Guillemin, E. Raffoux, D. Vitoux, S. Kogan, H. Soilihi, V. Lallemand-Breitenbach, J. Zhu, A. Janin, M.-T. Daniel, B. Gourmel, et al.
In Vivo Activation of cAMP Signaling Induces Growth Arrest and Differentiation in Acute Promyelocytic Leukemia
J. Exp. Med.,
November 18, 2002;
196(10):
1373 - 1380.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
