|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 February 2002, Vol. 99, No. 3, pp. 759-767
PERSPECTIVE
Acute promyelocytic leukemia: evolving therapeutic
strategies
Martin S. Tallman,
Chadi Nabhan,
James H. Feusner, and
Jacob M. Rowe
From the Division of Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical
School, Chicago, IL; Children's Hospital of Oakland, CA; and the
Department of Hematology and Bone Marrow Transplantation, Technion
Israel Institute of Technology, Rambam Medical Center, Haifa, Israel.
Acute promyelocytic leukemia (APL) is now the most curable subtype
of acute myeloid leukemia in adults. All-trans retinoic acid (ATRA), which induces differentiation of the leukemic cells into
mature granulocytes, represents the important advance. The incorporation of ATRA in induction results in a high complete remission
rate, leads to rapid resolution of the characteristic life-threatening
coagulopathy, and, most importantly, decreases the relapse rate
compared with treatment with chemotherapy alone. However, ATRA is
associated with unique toxicities not observed with conventional
cytotoxic chemotherapy. A number of clinical trials have been performed
to define the optimal role of ATRA in the treatment of patients. The
therapeutic strategies have rapidly evolved as a result of both single
institution and large cooperative group trials. Arsenic trioxide and
stem cell transplantation are effective treatments for patients with
APL who relapse after or are refractory to ATRA-based therapy. As
experience with ATRA and arsenic trioxide in patients with APL
accumulates, a number of important questions arise that need to be addressed.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
L. Leu and L. Mohassel
Arsenic trioxide as first-line treatment for acute promyelocytic leukemia
Am. J. Health Syst. Pharm.,
November 1, 2009;
66(21):
1913 - 1918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Platanias
Biological Responses to Arsenic Compounds
J. Biol. Chem.,
July 10, 2009;
284(28):
18583 - 18587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Derolf, S. Y. Kristinsson, T. M.-L. Andersson, O. Landgren, P. W. Dickman, and M. Bjorkholm
Improved patient survival for acute myeloid leukemia: a population-based study of 9729 patients diagnosed in Sweden between 1973 and 2005
Blood,
April 16, 2009;
113(16):
3666 - 3672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sassano, M. Lo Iacono, G. Antico, A. Jordan, S. Uddin, R. A. Calogero, and L. C. Platanias
Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins
Mol. Cancer Ther.,
March 1, 2009;
8(3):
615 - 625.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sanz, D. Grimwade, M. S. Tallman, B. Lowenberg, P. Fenaux, E. H. Estey, T. Naoe, E. Lengfelder, T. Buchner, H. Dohner, et al.
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Blood,
February 26, 2009;
113(9):
1875 - 1891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Zhang, L.-P. Song, Y. Huang, Q. Zhao, K.-W. Zhao, and G.-Q. Chen
Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid
Haematologica,
October 1, 2008;
93(10):
1480 - 1487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Ozeki and J. E. Shively
Differential cell fates induced by all-trans retinoic acid-treated HL-60 human leukemia cells
J. Leukoc. Biol.,
September 1, 2008;
84(3):
769 - 779.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Dolniak, E. Katsoulidis, N. Carayol, J. K. Altman, A. J. Redig, M. S. Tallman, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, and L. C. Platanias
Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2
J. Biol. Chem.,
May 2, 2008;
283(18):
12034 - 12042.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. de la Serna, P. Montesinos, E. Vellenga, C. Rayon, R. Parody, A. Leon, J. Esteve, J. M. Bergua, G. Milone, G. Deben, et al.
Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin
Blood,
April 1, 2008;
111(7):
3395 - 3402.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K. Altman, P. Yoon, E. Katsoulidis, B. Kroczynska, A. Sassano, A. J. Redig, H. Glaser, A. Jordan, M. S. Tallman, N. Hay, et al.
Regulatory Effects of Mammalian Target of Rapamycin-mediated Signals in the Generation of Arsenic Trioxide Responses
J. Biol. Chem.,
January 25, 2008;
283(4):
1992 - 2001.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Tallman and J. K. Altman
Curative Strategies in Acute Promyelocytic Leukemia
Hematology,
January 1, 2008;
2008(1):
391 - 399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J.L. Kaspers and C. M. Zwaan
Pediatric acute myeloid leukemia: towards high-quality cure of all patients
Haematologica,
November 1, 2007;
92(11):
1519 - 1532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Parekh, J. M. Polo, R. Shaknovich, P. Juszczynski, P. Lev, S. M. Ranuncolo, Y. Yin, U. Klein, G. Cattoretti, R. D. Favera, et al.
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
Blood,
September 15, 2007;
110(6):
2067 - 2074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Asou, Y. Kishimoto, H. Kiyoi, M. Okada, Y. Kawai, M. Tsuzuki, K. Horikawa, M. Matsuda, K. Shinagawa, T. Kobayashi, et al.
A randomized study with or without intensified maintenance chemotherapy in patients with acute promyelocytic leukemia who have become negative for PML-RAR{alpha} transcript after consolidation therapy: The Japan Adult Leukemia Study Group (JALSG) APL97 study
Blood,
July 1, 2007;
110(1):
59 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-B. Zhou, J. Zhang, Z.-Y. Wang, S.-J. Chen, and Z. Chen
Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy
Phil Trans R Soc B,
June 29, 2007;
362(1482):
959 - 971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sassano, E. Katsoulidis, G. Antico, J. K. Altman, A. J. Redig, S. Minucci, M. S. Tallman, and L. C. Platanias
Suppressive Effects of Statins on Acute Promyelocytic Leukemia Cells
Cancer Res.,
May 1, 2007;
67(9):
4524 - 4532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Lo-Coco, E. Ammatuna, and M. A. Sanz
Current treatment of acute promyelocytic leukemia
Haematologica,
March 1, 2007;
92(3):
289 - 291.
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Zheng, A. Seshire, B. Ruster, G. Bug, T. Beissert, E. Puccetti, D. Hoelzer, R. Henschler, and M. Ruthardt
Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RAR{alpha}-positive leukemic stem cells
Haematologica,
March 1, 2007;
92(3):
323 - 331.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Chen, R. Chan, S. Waxman, and Y. Jing
Buthionine Sulfoximine Enhancement of Arsenic Trioxide-Induced Apoptosis in Leukemia and Lymphoma Cells Is Mediated via Activation of c-Jun NH2-Terminal Kinase and Up-regulation of Death Receptors
Cancer Res.,
December 1, 2006;
66(23):
11416 - 11423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Yoon, N. Giafis, J. Smith, H. Mears, E. Katsoulidis, A. Sassano, J. Altman, A. J. Redig, M. S. Tallman, and L. C. Platanias
Activation of mammalian target of rapamycin and the p70 S6 kinase by arsenic trioxide in BCR-ABL-expressing cells.
Mol. Cancer Ther.,
November 1, 2006;
5(11):
2815 - 2823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. CAPLAN
All-Trans Retinoic Acid (ATRA) Syndrome Can Mimic Panic Disorder
Psychosomatics,
October 1, 2006;
47(5):
450 - 451.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Cimino, F. Lo-Coco, S. Fenu, L. Travaglini, E. Finolezzi, M. Mancini, M. Nanni, A. Careddu, F. Fazi, F. Padula, et al.
Sequential Valproic Acid/All-trans Retinoic Acid Treatment Reprograms Differentiation in Refractory and High-Risk Acute Myeloid Leukemia.
Cancer Res.,
September 1, 2006;
66(17):
8903 - 8911.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kannan-Thulasiraman, E. Katsoulidis, M. S. Tallman, J. S. C. Arthur, and L. C. Platanias
Activation of the Mitogen- and Stress-activated Kinase 1 by Arsenic Trioxide
J. Biol. Chem.,
August 11, 2006;
281(32):
22446 - 22452.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Giafis, E. Katsoulidis, A. Sassano, M. S. Tallman, L. S. Higgins, A. R. Nebreda, R. J. Davis, and L. C. Platanias
Role of the p38 Mitogen-Activated Protein Kinase Pathway in the Generation of Arsenic Trioxide-Dependent Cellular Responses.
Cancer Res.,
July 1, 2006;
66(13):
6763 - 6771.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. W. Milligan, K. Wheatley, T. Littlewood, J. I. O. Craig, A. K. Burnett, and for the NCRI Haematological Oncology Clinical Stud
Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of G-CSF and ATRA are not beneficial: results of the MRC AML-HR randomized trial
Blood,
June 15, 2006;
107(12):
4614 - 4622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lunghi, A. Costanzo, L. Salvatore, N. Noguera, L. Mazzera, A. Tabilio, F. Lo-Coco, M. Levrero, and A. Bonati
MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis
Blood,
June 1, 2006;
107(11):
4549 - 4553.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ghavamzadeh, K. Alimoghaddam, S. H. Ghaffari, S. Rostami, M. Jahani, R. Hosseini, A. Mossavi, E. Baybordi, A. Khodabadeh, M. Iravani, et al.
Treatment of acute promyelocytic leukemia with arsenic trioxide without ATRA and/or chemotherapy
Ann. Onc.,
January 1, 2006;
17(1):
131 - 134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sanz
Treatment of Acute Promyelocytic Leukemia
Hematology,
January 1, 2006;
2006(1):
147 - 155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Lo-Coco and E. Ammatuna
The Biology of Acute Promyelocytic Leukemia and Its Impact on Diagnosis and Treatment
Hematology,
January 1, 2006;
2006(1):
156 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sanz, M. S. Tallman, and F. Lo-Coco
Practice Points, Consensus, and Controversial Issues in the Management of Patients with Newly Diagnosed Acute Promyelocytic Leukemia
Oncologist,
November 1, 2005;
10(10):
806 - 814.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. J. Ortega, L. Madero, G. Martin, A. Verdeguer, P. Garcia, R. Parody, J. Fuster, A. Molines, A. Novo, G. Deben, et al.
Treatment With All-Trans Retinoic Acid and Anthracycline Monochemotherapy for Children With Acute Promyelocytic Leukemia: A Multicenter Study by the PETHEMA Group
J. Clin. Oncol.,
October 20, 2005;
23(30):
7632 - 7640.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Hampson, H. Chahal, F. Khanim, R. Hayden, A. Mulder, L. K. Assi, C. M. Bunce, and J. M. Lord
PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC
Blood,
August 15, 2005;
106(4):
1362 - 1368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Testi, A. Biondi, F. L. Coco, M. L. Moleti, F. Giona, M. Vignetti, G. Menna, F. Locatelli, A. Pession, E. Barisone, et al.
GIMEMA-AIEOPAIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children
Blood,
July 15, 2005;
106(2):
447 - 453.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sanz, M. S. Tallman, and F. Lo-Coco
Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia
Blood,
April 15, 2005;
105(8):
3019 - 3025.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Douer and M. S. Tallman
Arsenic Trioxide: New Clinical Experience With an Old Medication in Hematologic Malignancies
J. Clin. Oncol.,
April 1, 2005;
23(10):
2396 - 2410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Rotem, A. Heyfets, O. Fingrut, D. Blickstein, M. Shaklai, and E. Flescher
Jasmonates: Novel Anticancer Agents Acting Directly and Selectively on Human Cancer Cell Mitochondria
Cancer Res.,
March 1, 2005;
65(5):
1984 - 1993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lal, Y. Li, J. Smith, A. Sassano, S. Uddin, S. Parmar, M. S. Tallman, S. Minucci, N. Hay, and L. C. Platanias
Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
Blood,
February 15, 2005;
105(4):
1669 - 1677.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. de Botton, A. Fawaz, S. Chevret, H. Dombret, X. Thomas, M. Sanz, A. Guerci, J. San Miguel, J. de la Serna, A.M. Stoppa, et al.
Autologous and Allogeneic Stem-Cell Transplantation As Salvage Treatment of Acute Promyelocytic Leukemia Initially Treated With All-Trans-Retinoic Acid: A Retrospective Analysis of the European Acute Promyelocytic Leukemia Group
J. Clin. Oncol.,
January 1, 2005;
23(1):
120 - 126.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Rigas and K. H. Dragnev
Emerging Role of Rexinoids in Non-Small Cell Lung Cancer: Focus on Bexarotene
Oncologist,
January 1, 2005;
10(1):
22 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gettinger, I. Shapira, N. Scheinfeld, and M. Grossbard
Complications of Therapy in Cancer Patients: CASE 2. Scrotal Ulceration During All-Trans-Retinoic Acid Therapy for Acute Promyelocytic Leukemia
J. Clin. Oncol.,
November 15, 2004;
22(22):
4648 - 4649.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Lo-Coco, G. Cimino, M. Breccia, N. I. Noguera, D. Diverio, E. Finolezzi, E. M. Pogliani, E. Di Bona, C. Micalizzi, M. Kropp, et al.
Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia
Blood,
October 1, 2004;
104(7):
1995 - 1999.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Battistella, L. D Burry, and J. T Seki
Retinoic acid syndrome after one dose of all-transretinoic acid
Journal of Oncology Pharmacy Practice,
September 1, 2004;
10(3):
149 - 154.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Levis, R. Pham, B. D. Smith, and D. Small
In vitro studies of a FLT3 inhibitor combined with chemotherapy: sequence of administration is important to achieve synergistic cytotoxic effects
Blood,
August 15, 2004;
104(4):
1145 - 1150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Lunghi, A. Costanzo, M. Levrero, and A. Bonati
Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells
Blood,
July 15, 2004;
104(2):
519 - 525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sanz, G. Martin, M. Gonzalez, A. Leon, C. Rayon, C. Rivas, D. Colomer, E. Amutio, F. J. Capote, G. A. Milone, et al.
Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group
Blood,
February 15, 2004;
103(4):
1237 - 1243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. G. Gilliland, C. T. Jordan, and C. A. Felix
The Molecular Basis of Leukemia
Hematology,
January 1, 2004;
2004(1):
80 - 97.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Stone, M. R. O'Donnell, and M. A. Sekeres
Acute Myeloid Leukemia
Hematology,
January 1, 2004;
2004(1):
98 - 117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schnittger, M. Weisser, C. Schoch, W. Hiddemann, T. Haferlach, and W. Kern
New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts
Blood,
October 15, 2003;
102(8):
2746 - 2755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kambhampati, Y. Li, A. Verma, A. Sassano, B. Majchrzak, D. K. Deb, S. Parmar, N. Giafis, D. V. Kalvakolanu, A. Rahman, et al.
Activation of Protein Kinase C{delta} by All-trans-retinoic Acid
J. Biol. Chem.,
August 29, 2003;
278(35):
32544 - 32551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-Y. Au, C. R. Kumana, M. Kou, R. Mak, G. C. F. Chan, C.-W. Lam, and Y.-L. Kwong
Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia
Blood,
July 1, 2003;
102(1):
407 - 408.
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. C. Platanias
Map kinase signaling pathways and hematologic malignancies
Blood,
June 15, 2003;
101(12):
4667 - 4679.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Y. Au, A. K. W. Lie, C. S. Chim, R. Liang, S. K. Ma, C. H. Chan, Y. K. Mak, Y. T. Chen, C. C. So, Y. M. Yeung, et al.
Arsenic trioxide in comparison with chemotherapy and bone marrow transplantation for the treatment of relapsed acute promyelocytic leukaemia
Ann. Onc.,
May 1, 2003;
14(5):
752 - 757.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Verma, M. Mohindru, D. K. Deb, A. Sassano, S. Kambhampati, F. Ravandi, S. Minucci, D. V. Kalvakolanu, and L. C. Platanias
Activation of Rac1 and the p38 Mitogen-activated Protein Kinase Pathway in Response to Arsenic Trioxide
J. Biol. Chem.,
November 15, 2002;
277(47):
44988 - 44995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Kelly, J. L. Kutok, I. R. Williams, C. L. Boulton, S. M. Amaral, D. P. Curley, T. J. Ley, and D. G. Gilliland
PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model
PNAS,
June 11, 2002;
99(12):
8283 - 8288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Giles, A. Keating, A. H. Goldstone, I. Avivi, C. L. Willman, and H. M. Kantarjian
Acute Myeloid Leukemia
Hematology,
January 1, 2002;
2002(1):
73 - 110.
[Abstract]
[Full Text]
|
|
|
|
|
