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Blood, 15 February 2002, Vol. 99, No. 4, pp. 1117-1129
CHEMOKINES
Stromal cell-derived factor 1 regulates primitive
hematopoiesis by suppressing apoptosis and by promoting
G0/G1 transition in CD34+ cells:
evidence for an autocrine/paracrine mechanism
Jean-Jacques Lataillade,
Denis Clay,
Philippe Bourin,
Françis Hérodin,
Catherine Dupuy,
Claude Jasmin, and
Marie-Caroline Le Bousse-Kerdilès
From the Laboratoire d'Immunologie Cellulaire, Centre
de Transfusion Sanguine des Armées Jean Julliard, Clamart Cedex,
France; Institut National de la Santé et de la Recherche
Médicale, Unité 268, Institut André Lwoff,
Hôpital Paul Brousse, Paul Villejuif, France; Centre de Recherche
du Service de Santé des Armées, maquis du
Grésivaudant, La Tronche Cedex, France.
The stromal cell-derived factor 1 (SDF-1) chemokine has various
effects on hematopoietic cell functions. Its role in migration and
homing of hematopoietic progenitors is currently well established. Previously it was shown that SDF-1 stimulates myeloid progenitor proliferation in synergy with cytokines. Results of this study indicate
that SDF-1 alone promotes survival of purified CD34+ cells
from human unmobilized peripheral blood (PB) by counteracting apoptosis
as demonstrated by its capacity to reduce DNA fragmentation, annexin-V+ cell number, and APO2.7 detection and to
modulate bcl-2 homolog protein expression. The study demonstrates that
SDF-1, produced by sorted CD34+CD38+ cells and
over-released in response to cell damage, exerts an antiapoptotic
effect on CD34+ cells through an autocrine/paracrine
regulatory loop. SDF-1 participates in the autonomous survival of
circulating CD34+ cells and its effect required activation
of the phosphotidyl inositol 3 kinase (PI3-K)/Akt axis. Cell sorting
based on Hoechst/pyroninY fluorescences shows that SDF-1 production is
restricted to cycling CD34+ cells. SDF-1 triggers
G0 quiescent cells in G1 phase and, in synergy
with thrombopoietin or Steel factor, makes CD34+ cells
progress through S+G2/M phases of cell cycle. By assessing sorted CD34+CD38 and
CD34+CD38+ in semisolid culture, the study
demonstrates that SDF-1 promotes survival of clonogenic progenitors. In
conclusion, the results are the first to indicate a role for endogenous
SDF-1 in primitive hematopoiesis regulation as a survival and cell
cycle priming factor for circulating CD34+ cells. The
proposal is made that SDF-1 may contribute to hematopoiesis homeostasis
by participating in the autonomous survival and cycling of progenitors
under physiologic conditions and by protecting them from cell
aggression in stress situations.
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|
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|
|
|
|
|
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102(12):
1471 - 1482.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
Y. Nie, Y.-C. Han, and Y.-R. Zou
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205(4):
777 - 783.
[Abstract]
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|
|
|
|
|
|
|
F. Rezzoug, Y. Huang, M. K. Tanner, M. Wysoczynski, C. L. Schanie, P. M. Chilton, M. Z. Ratajczak, I. J. Fugier-Vivier, and S. T. Ildstad
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180(1):
49 - 57.
[Abstract]
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|
|
|
|
|
|
|
L. Jin, Y. Tabe, S. Konoplev, Y. Xu, C. E. Leysath, H. Lu, S. Kimura, A. Ohsaka, M.-B. Rios, L. Calvert, et al.
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7(1):
48 - 58.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
J. Juarez, R. Baraz, S. Gaundar, K. Bradstock, and L. Bendall
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92(4):
450 - 459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Zheng, S.-h. Oh, Y. Jung, and B. E. Petersen
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169(6):
2066 - 2074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Zeng, I. J. Samudio, M. Munsell, J. An, Z. Huang, E. Estey, M. Andreeff, and M. Konopleva
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
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5(12):
3113 - 3121.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wimmer, S. K. Khaldoyanidi, M. Judex, N. Serobyan, R. G. DiScipio, and I. U. Schraufstatter
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108(12):
3722 - 3729.
[Abstract]
[Full Text]
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|
|
|
|
|
|
|
A. Foudi, P. Jarrier, Y. Zhang, M. Wittner, J.-F. Geay, Y. Lecluse, T. Nagasawa, W. Vainchenker, and F. Louache
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice
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March 15, 2006;
107(6):
2243 - 2251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Burger and T. J. Kipps
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March 1, 2006;
107(5):
1761 - 1767.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Muguruma, T. Yahata, H. Miyatake, T. Sato, T. Uno, J. Itoh, S. Kato, M. Ito, T. Hotta, and K. Ando
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107(5):
1878 - 1887.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Infantino, B. Moepps, and M. Thelen
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176(4):
2197 - 2207.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Haneline, H. White, F.-C. Yang, S. Chen, C. Orschell, R. Kapur, and D. A. Ingram
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February 15, 2006;
107(4):
1375 - 1382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. M. Woerner, N. M. Warrington, A. L. Kung, A. Perry, and J. B. Rubin
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65(24):
11392 - 11399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Gerli, C. Vanelli, O. Turri, M. Erario, A. Gardellini, M. Pugliano, and M. L. Biondi
SDF1-3'A Gene Polymorphism Is Associated with Chronic Myeloproliferative Disease and Thrombotic Events
Clin. Chem.,
December 1, 2005;
51(12):
2411 - 2414.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. L. Semerad, M. J. Christopher, F. Liu, B. Short, P. J. Simmons, I. Winkler, J.-P. Levesque, J. Chappel, F. P. Ross, and D. C. Link
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
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November 1, 2005;
106(9):
3020 - 3027.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Dalakas, P. N. Newsome, D. J. Harrison, and J. N. Plevris
Hematopoietic stem cell trafficking in liver injury
FASEB J,
August 1, 2005;
19(10):
1225 - 1231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. Lataillade, D. Clay, C. David, L. Boutin, B. Guerton, M. Drouet, F. Herodin, and M.-C. Le Bousse-Kerdiles
Phenotypic and functional characteristics of CD34+ cells are related to their anatomical environment: is their versatility a prerequisite for their bio-availability?
J. Leukoc. Biol.,
May 1, 2005;
77(5):
634 - 643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bendall, R. Baraz, J. Juarez, W. Shen, and K. F. Bradstock
Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1{alpha} in Acute Lymphoblastic Leukemia
Cancer Res.,
April 15, 2005;
65(8):
3290 - 3298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Smith, P. A. Johanesen, M. K. Wendt, D. G. Binion, and M. B. Dwinell
CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity
Am J Physiol Gastrointest Liver Physiol,
February 1, 2005;
288(2):
G316 - G326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Piovan, V. Tosello, S. Indraccolo, A. Cabrelle, I. Baesso, L. Trentin, R. Zamarchi, H. Tamamura, N. Fujii, G. Semenzato, et al.
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation
Blood,
February 1, 2005;
105(3):
931 - 939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Jaleel, A. C. Tsai, S. Sarkar, P. V. Freedman, and L. P. Rubin
Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival
Mol. Hum. Reprod.,
December 1, 2004;
10(12):
901 - 909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. De Falco, D. Porcelli, A. R. Torella, S. Straino, M. G. Iachininoto, A. Orlandi, S. Truffa, P. Biglioli, M. Napolitano, M. C. Capogrossi, et al.
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
Blood,
December 1, 2004;
104(12):
3472 - 3482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Marchesi, P. Monti, B. E. Leone, A. Zerbi, A. Vecchi, L. Piemonti, A. Mantovani, and P. Allavena
Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4
Cancer Res.,
November 15, 2004;
64(22):
8420 - 8427.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. C. Rombouts, B. Pavic, B. Lowenberg, and R. E. Ploemacher
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
Blood,
July 15, 2004;
104(2):
550 - 557.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-C. Lee, T.-H. Lee, S. Avraham, and H. K. Avraham
Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1{alpha} in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells
Mol. Cancer Res.,
June 1, 2004;
2(6):
327 - 338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Dwinell, H. Ogawa, K. E. Barrett, and M. F. Kagnoff
SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4
Am J Physiol Gastrointest Liver Physiol,
May 1, 2004;
286(5):
G844 - G850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tavor, I. Petit, S. Porozov, A. Avigdor, A. Dar, L. Leider-Trejo, N. Shemtov, V. Deutsch, E. Naparstek, A. Nagler, et al.
CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice
Cancer Res.,
April 15, 2004;
64(8):
2817 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kahn, T. Byk, L. Jansson-Sjostrand, I. Petit, S. Shivtiel, A. Nagler, I. Hardan, V. Deutsch, Z. Gazit, D. Gazit, et al.
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation
Blood,
April 15, 2004;
103(8):
2942 - 2949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Kayali, K. Van Gunst, I. L. Campbell, A. Stotland, M. Kritzik, G. Liu, M. Flodstrom-Tullberg, Y.-Q. Zhang, and N. Sarvetnick
The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas
J. Cell Biol.,
November 24, 2003;
163(4):
859 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Laakko and R. L. Juliano
Adhesion Regulation of Stromal Cell-derived Factor-1 Activation of ERK in Lymphocytes by Phosphatases
J. Biol. Chem.,
August 22, 2003;
278(34):
31621 - 31628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tarte, F. Zhan, J. De Vos, B. Klein, and J. Shaughnessy Jr
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation
Blood,
July 15, 2003;
102(2):
592 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. S. Zeelenberg, L. Ruuls-Van Stalle, and E. Roos
The Chemokine Receptor CXCR4 Is Required for Outgrowth of Colon Carcinoma Micrometastases
Cancer Res.,
July 1, 2003;
63(13):
3833 - 3839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Giron-Michel, A. Caignard, M. Fogli, D. Brouty-Boye, D. Briard, M. van Dijk, R. Meazza, S. Ferrini, C. Lebousse-Kerdiles, D. Clay, et al.
Differential STAT3, STAT5, and NF-{kappa}B activation in human hematopoietic progenitors by endogenous interleukin-15: implications in the expression of functional molecules
Blood,
July 1, 2003;
102(1):
109 - 117.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Papayannopoulou, G. V. Priestley, H. Bonig, and B. Nakamoto
The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization
Blood,
June 15, 2003;
101(12):
4739 - 4747.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Broxmeyer, L. Kohli, C. H. Kim, Y. Lee, C. Mantel, S. Cooper, G. Hangoc, M. Shaheen, X. Li, and D. W. Clapp
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G{alpha}i proteins and enhances engraftment of competitive, repopulating stem cells
J. Leukoc. Biol.,
May 1, 2003;
73(5):
630 - 638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yahata, K. Ando, T. Sato, H. Miyatake, Y. Nakamura, Y. Muguruma, S. Kato, and T. Hotta
A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow
Blood,
April 15, 2003;
101(8):
2905 - 2913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Herodin, P. Bourin, J.-F. Mayol, J.-J. Lataillade, and M. Drouet
Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma -irradiation promotes survival
Blood,
April 1, 2003;
101(7):
2609 - 2616.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Hwang, J. H. Hwang, H. K. Chung, D. W. Kim, E. S. Hwang, J. M. Suh, H. Kim, K.-H. You, O-Y. Kwon, H. K. Ro, et al.
CXC Chemokine Receptor 4 Expression and Function in Human Anaplastic Thyroid Cancer Cells
J. Clin. Endocrinol. Metab.,
January 1, 2003;
88(1):
408 - 416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Broxmeyer, S. Cooper, L. Kohli, G. Hangoc, Y. Lee, C. Mantel, D. W. Clapp, and C. H. Kim
Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo
J. Immunol.,
January 1, 2003;
170(1):
421 - 429.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Cottler-Fox, T. Lapidot, I. Petit, O. Kollet, J. F. DiPersio, D. Link, and S. Devine
Stem Cell Mobilization
Hematology,
January 1, 2003;
2003(1):
419 - 437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Murakami, W. Maki, A. R. Cardones, H. Fang, A. Tun Kyi, F. O. Nestle, and S. T. Hwang
Expression of CXC Chemokine Receptor-4 Enhances the Pulmonary Metastatic Potential of Murine B16 Melanoma Cells
Cancer Res.,
December 1, 2002;
62(24):
7328 - 7334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Kollet, I. Petit, J. Kahn, S. Samira, A. Dar, A. Peled, V. Deutsch, M. Gunetti, W. Piacibello, A. Nagler, et al.
Human CD34+CXCR4- sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation
Blood,
September 26, 2002;
100(8):
2778 - 2786.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fukuda, R. G. Foster, S. B. Porter, and L. M. Pelus
The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34+ cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells
Blood,
September 18, 2002;
100(7):
2463 - 2471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ptasznik, E. Urbanowska, S. Chinta, M. A. Costa, B. A. Katz, M. A. Stanislaus, G. Demir, D. Linnekin, Z. K. Pan, and A. M. Gewirtz
Crosstalk Between BCR/ABL Oncoprotein and CXCR4 Signaling through a Src Family Kinase in Human Leukemia Cells
J. Exp. Med.,
September 2, 2002;
196(5):
667 - 678.
[Abstract]
[Full Text]
[PDF]
|
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