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Blood, 15 February 2002, Vol. 99, No. 4, pp. 1327-1331
NEOPLASIA
Impact of the lymphoma idiotype on in vivo tumor protection in a
vaccination model based on targeting antigens to
antigen-presenting cells
Konrad Kronenberger,
Andreas Dieckmann,
Michael Selmayr,
John Strehl,
Ulrich Wahl,
Horst Lindhofer,
Georg Kraal, and
Ralph Mocikat
From GSF-Institut für Molekulare Immunologie,
Munich, Germany; GSF-Institut für Klinische Molekularbiologie und
Tumorgenetik, Munich, Germany; Department of Molecular Cell Biology,
Vrije Universiteit, Amsterdam, The Netherlands; and Medizinische Klinik
der Universität Bonn, Germany.
Trioma cell vaccination is a potent new immunologic approach for
the therapy of malignant B-cell lymphoma. It is based on targeting
tumor antigens to internalizing receptors on antigen-presenting cells
(APCs). Tumor cells are fused to an APC-specific hybridoma, where they
are converted to trioma cells that include potentially all
lymphoma-derived antigens and that express the APC-binding arm. In this
study, the mechanisms of trioma-mediated tumor immunity in
immunocompetent mice were dissected, and it was shown in this model
system that humoral anti-idiotypic immunity is indeed detectable after
idiotype-specific immunization but that it does not reflect the degree
of tumor protection obtained in vivo. Immunization against the idiotype
alone was not sufficient for efficient tumor rejection in vivo.
Targeting tumor antigens to APCs is only successful in terms of
inducing tumor protection when designed as a polyvalent vaccination protocol.
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