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Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 February 2002, Vol. 99, No. 4, pp. 1449-1457 TRANSPLANTATION Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation Defu Zeng, Petra Hoffmann, Fengshuo Lan, Philip Huie, John Higgins, and Samuel Strober From the Department of Medicine, Division of Immunology and Rheumatology, and the Department of Pathology, Stanford University School of Medicine, CA. The "conventional" NK1.1 T cells from mouse blood and marrow were compared with regard to surface receptors, cytokine secretion, and function. Most blood NK1.1 CD4+ and CD8+ T cells expressed the naive CD44int/loCD62LhiCD45RBhi T-cell phenotype typical of those in the peripheral lymphoid tissues. In contrast, most marrow NK1.1 CD4+ and CD8+ T cells expressed an unusual CD44hiCD62LhiCD45RBhi phenotype. The blood NK1.1 CD4+ T cells had a naive T-helper cytokine profile and a potent capacity to induce lethal graft versus host (GVH) disease in a C57BL/6 donor to a BALB/c host bone marrow transplantation model. In contrast, the marrow NK1.1 CD4+ T cells had a Th0 cytokine profile and failed to induce lethal GVH disease, even at 20-fold higher numbers than those from the blood. NK1.1 CD8+ T cells from the blood but not the marrow induced lethal GVH disease. Nevertheless, the marrow NK1.1 CD8+ T cells induced potent antitumor activity that was augmented by marrow NK1.1 CD4+ T cells and facilitated hematopoietic progenitor engraftment. The inability of marrow CD4+ and CD8+ T cells to induce GVH disease was associated with their inability to expand in the blood and gut of allogeneic recipients. Because neither the purified marrow CD4+ or CD8+ T cells induced GVH disease, their unique features are desirable for inclusion in allogeneic bone marrow or hematopoietic progenitor transplants. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Li, Y. Chen, W. He, T. Yi, D. Zhao, C. Zhang, C.-L. Lin, I. Todorov, F. Kandeel, S. Forman, et al. Anti-CD3 preconditioning separates GVL from GVHD via modulating host dendritic cell and donor T-cell migration in recipients conditioned with TBI Blood, January 22, 2009; 113(4): 953 - 962. [Abstract] [Full Text] [PDF] M. Paiardini, B. Cervasi, J. C. Engram, S. N. Gordon, N. R. Klatt, A. Muthukumar, J. Else, R. S. Mittler, S. I. Staprans, D. L. Sodora, et al. 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