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Related Collections Hematopoiesis and Stem Cells Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 March 2002, Vol. 99, No. 5, pp. 1866-1869 BRIEF REPORT Requirement of Gab2 for mast cell development and KitL/c-Kit signaling Keigo Nishida, Lin Wang, Eiichi Morii, Sung Joo Park, Masahiro Narimatsu, Shousaku Itoh, Satoru Yamasaki, Masahiro Fujishima, Katsuhiko Ishihara, Masahiko Hibi, Yukihiko Kitamura, and Toshio Hirano From the Department of Molecular Oncology (C-7) and the Department of Pathology (C-2), Osaka University Graduate School of Medicine; the Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology, 1-7-22, Suehirocho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan; and the Biological Institute, Faculty of Science, Yamaguchi University, Japan. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell development depends on stem cell factor (Kit ligand) and its receptor, c-Kit. Gab2 is an adaptor molecule containing a pleckstrin homology domain and potential binding sites for SH2 and SH3 domains. Gab2 is phosphorylated on tyrosine after stimulation with cytokines and growth factors, including KitL. Gab2-deficient mice were created to define the physiological requirement for Gab2 in KitL/c-Kit signaling and mast cell development. In Gab2-deficient mice, the number of mast cells was reduced markedly in the stomach and less severely in the skin. Bone marrow-derived mast cells (BMMCs) from the Gab2-deficient mice grew poorly in response to KitL. KitL-induced ERK MAP kinase and Akt activation were impaired in Gab2-deficient BMMCs. These data indicate that Gab2 is required for mast cell development and KitL/c-Kit signaling. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Nishida, A. Hasegawa, S. Nakae, K. Oboki, H. Saito, S. Yamasaki, and T. Hirano Zinc transporter Znt5/Slc30a5 is required for the mast cell-mediated delayed-type allergic reaction but not the immediate-type reaction J. Exp. Med., June 8, 2009; 206(6): 1351 - 1364. [Abstract] [Full Text] [PDF] L. A. Samayawardhena and C. J. Pallen Protein-tyrosine Phosphatase {alpha} Regulates Stem Cell Factor-dependent c-Kit Activation and Migration of Mast Cells J. Biol. Chem., October 24, 2008; 283(43): 29175 - 29185. [Abstract] [Full Text] [PDF] J. Sun, M. Pedersen, and L. Ronnstrand Gab2 Is Involved in Differential Phosphoinositide 3-Kinase Signaling by Two Splice Forms of c-Kit J. Biol. 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