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Blood, 1 March 2002, Vol. 99, No. 5, pp. 1870-1872
BRIEF REPORT
Allogenic fetal liver cells have a distinct competitive
engraftment advantage over adult bone marrow cells when infused into
fetal as compared with adult severe combined immunodeficient
recipients
Patricia A. Taylor,
Ronald
T. McElmurry,
Christopher J. Lees,
David E. Harrison, and
Bruce R. Blazar
From the University of Minnesota Cancer Center and
Department of Pediatrics, Division of Bone Marrow Transplantation,
Minneapolis; and The Jackson Laboratories, Bar Harbor, ME.
In utero transplantation (IUT) is becoming a viable option for the
treatment of various immune and metabolic disorders diagnosed early in
gestation. In this study, donor fetal liver cells had a 10-fold
competitive engraftment advantage relative to adult bone marrow in
allogeneic fetal severe combined immunodeficient (SCID) recipients
compared with adult recipients. In contrast, adult bone marrow cells
engrafted slightly better than fetal liver cells in allogeneic adult
SCID transplant recipients. By using different ratios of fetal and
adult cell mixtures, fetal liver cells repopulated 8.2 times better
than adult bone marrow cells in fetal recipients, but only 0.8 times as
well in adult recipients. Fetal SCID recipients were more permissive to
an allogeneic donor graft than adult recipients. These data indicate
that the recipient microenvironment may regulate the engraftment
efficiency of a given stem cell source and suggest that the use of cord
blood should be tested in clinical IUT.
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