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Related Collections Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 March 2002, Vol. 99, No. 6, pp. 1928-1937 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study Moshe Talpaz, Richard T. Silver, Brian J. Druker, John M. Goldman, Carlo Gambacorti-Passerini, Francois Guilhot, Charles A. Schiffer, Thomas Fischer, Michael W. N. Deininger, Anne L. Lennard, Andreas Hochhaus, Oliver G. Ottmann, Alois Gratwohl, Michele Baccarani, Richard Stone, Sante Tura, Francois-Xavier Mahon, Sofia Fernandes-Reese, Insa Gathmann, Renaud Capdeville, Hagop M. Kantarjian, and Charles L. Sawyers From the M. D. Anderson Cancer Center, Houston, TX; New York-Presbyterian Hospital Weill Medical College of Cornell University, New York, NY; Division of Hematology, Oregon Health Sciences University, Portland; Department of Haematology, Hammersmith Hospital/ICSM, London, United Kingdom; Hematology Section, San Gerardo Hospital, Monza, Italy; Department of Experimental Oncology, National Cancer Institute, Milan, Italy; Department of Oncology Hematology and Cell Therapy, C.H.U de Poitiers, Poitiers, France; Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI; Universitätsklinikum, Medizinische Klinik und Poliklinik, Mainz, Germany; Abteilung Haematologie/Onkologie, Universität Leipzig, Leipzig, Germany; Department of Haematology, Royal Victoria Infirmary, University of Newcastle upon Tyne, United Kingdom; Medizinische Universitätsklinik Mannheim der Universität Heidelberg, Mannheim, Germany; Medizinische Klinik III, Johan Wolfgang Goethe Universität, Frankfurt, Germany; Division of Hematology, Universitätsklinik, Kantonspital, Basel, Switzerland; Division of Hematology, Udine University Hospital, Udine, Italy; Dana Farber Cancer Institute, Boston, MA; Instituto di Ematologia, Ospedale Policlinicl Sant'Orsola-Malpighi, Bologna, Italy; Laboratoire de Greffe de Moelle, Universite Victor Segalen, Bordeaux, France; Novartis Pharma AG, Basel, Switzerland; Department of Medicine and Molecular Biology Institute, University of California at Los Angeles, CA. Chronic myelogenous leukemia (CML) is caused by expression of the BCR-ABL tyrosine kinase oncogene, the product of the t(9;22) Philadelphia translocation. Patients with CML in accelerated phase have rapidly progressive disease and are characteristically unresponsive to existing therapies. Imatinib (formerly STI571) is a rationally developed, orally administered inhibitor of the Bcr-Abl kinase. A total of 235 CML patients were enrolled in this study, of whom 181 had a confirmed diagnosis of accelerated phase. Patients were treated with imatinib at 400 or 600 mg/d and were evaluated for hematologic and cytogenetic response, time to progression, survival, and toxicity. Imatinib induced hematologic response in 82% of patients and sustained hematologic responses lasting at least 4 weeks in 69% (complete in 34%). The rate of major cytogenetic response was 24% (complete in 17%). Estimated 12-month progression-free and overall survival rates were 59% and 74%, respectively. Nonhematologic toxicity was usually mild or moderate, and hematologic toxicity was manageable. In comparison to 400 mg, imatinib doses of 600 mg/d led to more cytogenetic responses (28% compared to 16%), longer duration of response (79% compared to 57% at 12 months), time to disease progression (67% compared to 44% at 12 months), and overall survival (78% compared to 65% at 12 months), with no clinically relevant increase in toxicity. Orally administered imatinib is an effective and well-tolerated treatment for patients with CML in accelerated phase. A daily dose of 600 mg is more effective than 400 mg, with similar toxicity. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Capdeville, T. Krahnke, A. Hatfield, J. M. Ford, I. Van Hoomissen, and I. 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