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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hanawa, H. Articles by Ochi, A. Search for Related Content PubMed PubMed Citation Articles by Hanawa, H. Articles by Ochi, A. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 March 2002, Vol. 99, No. 6, pp. 2138-2145 IMMUNOBIOLOGY A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28 Haruo Hanawa, Yong Ma, Sebastian A. Mikolajczak, Matthew L. Charles, Tetsuya Yoshida, Ryoko Yoshida, Craig A. Strathdee, David W. Litchfield, and Atsuo Ochi From the John P. Robarts Research Institute, the Department of Microbiology and Immunology, and the Department of Biochemistry, University of Western Ontario; First Department of Internal Medicine, Niigata University, Japan; Immunex Corporation, Seattle, WA. We have characterized a splice variant (isoform) of the human CD28 T cell costimulatory receptor. The nucleotide sequence of this CD28 isoform was identical to that of CD28 in the signal peptide, the transmembrane domain, and the cytoplasmic tail, but it was missing a large segment of the extracellular ligand-binding domain, which is encoded by the second exon. This isoform (CD28i), whose message level exceeded 25% of CD28, was a transmembrane homodimer. CD28i was found noncovalently associated with CD28 and was tyrosine-phosphorylated/PI3-kinase-complexed following the crosslinking of CD28, and the CD28 costimulatory signal was enhanced in T cells expressing CD28i. These data demonstrate that CD28i, via noncovalent association with CD28, plays a role as a costimulatory signal amplifier in human T cells. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. K. Kapsogeorgou, H. M. Moutsopoulos, and M. N. Manoussakis A Novel B7-2 (CD86) Splice Variant with a Putative Negative Regulatory Role J. Immunol., March 15, 2008; 180(6): 3815 - 3823. [Abstract] [Full Text] [PDF] X. Chen, D. S. J. Allan, K. Krzewski, B. Ge, H. Kopcow, and J. L. Strominger CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells PNAS, July 5, 2006; 103(27): 10346 - 10351. [Abstract] [Full Text] [PDF] B. Y. Ma, S. A. Mikolajczak, A. Danesh, K. A. Hosiawa, C. M. Cameron, A. Takaori-Kondo, T. Uchiyama, D. J. Kelvin, and A. Ochi The expression and the regulatory role of OX40 and 4-1BB heterodimer in activated human T cells Blood, September 15, 2005; 106(6): 2002 - 2010. [Abstract] [Full Text] [PDF] S. A. Mikolajczak, B. Y. Ma, T. Yoshida, R. Yoshida, D. J. Kelvin, and A. Ochi The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells J. Exp. Med., April 5, 2004; 199(7): 1025 - 1031. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020