SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Steensma, D. P. Articles by Tefferi, A. Search for Related Content PubMed PubMed Citation Articles by Steensma, D. P. Articles by Tefferi, A. Related Collections Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 March 2002, Vol. 99, No. 6, pp. 2252-2254 BRIEF REPORT Etanercept, a soluble tumor necrosis factor receptor, palliates constitutional symptoms in patients with myelofibrosis with myeloid metaplasia: results of a pilot study David P. Steensma, Ruben A. Mesa, Chin-Yang Li, Leigh Gray, and Ayalew Tefferi From the Division of Hematology, Department of Internal Medicine, and Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Patients with myelofibrosis with myeloid metaplasia (MMM) often experience debilitating constitutional symptoms such as drenching night sweats, profound fatigue, unexplained fevers, and unintentional weight loss. Tumor necrosis factor (TNF) contributes to organ fibrosis and hypercatabolic symptoms in a variety of disease states. We conducted an open-label pilot study of etanercept, a soluble TNF receptor, administered at a dose of 25 mg subcutaneously twice weekly for up to 24 weeks in 22 patients with MMM. Of 20 evaluable patients, 12 (60%) experienced an improvement in constitutional symptoms, and 4 (20%) had an objective response (improvement in peripheral cytopenias or spleen size). The degree of marrow fibrosis was unchanged, and only minor changes in overall marrow cellularity were observed. Toxicity was mild, with injection site reactions (20%) and minor infections (10%) as the most common side effects. One patient developed reversible pancytopenia. Etanercept may be useful for palliation of constitutional symptoms in MMM. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. P. Steensma and R. E. Richard Myeloproliferative disorders ASH Self-Assessment Program, January 1, 2007; 2007(1): 172 - 227. [Full Text] [PDF] C. Arana-Yi, A. Quintas-Cardama, F. Giles, D. Thomas, A. Carrasco-Yalan, J. Cortes, H. Kantarjian, and S. Verstovsek Advances in the Therapy of Chronic Idiopathic Myelofibrosis Oncologist, September 1, 2006; 11(8): 929 - 943. [Abstract] [Full Text] [PDF] A. Tefferi Pathogenesis of Myelofibrosis With Myeloid Metaplasia J. Clin. Oncol., November 20, 2005; 23(33): 8520 - 8530. [Abstract] [Full Text] [PDF] R. A. Mesa, D. P. Stensma, C. Y. Li, A. Hoering, J. B. Allred, H. L. Powell, and A. Tefferi Phase II Study of the Combination of Low-Dose Thalidomide, Prednisone, and Etanercept (PET Regimen) in the Treatment of Anemia, Splenomegaly, and Constitutional Symptoms Associated with Myelofibrosis with Myeloid Metaplasia (MMM). Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 2576 - 2576. [Abstract] S. Madhusudan, S. R. Muthuramalingam, J. P. Braybrooke, S. Wilner, K. Kaur, C. Han, S. Hoare, F. Balkwill, and T. S. Ganesan Study of Etanercept, a Tumor Necrosis Factor-Alpha Inhibitor, in Recurrent Ovarian Cancer J. Clin. Oncol., September 1, 2005; 23(25): 5950 - 5959. [Abstract] [Full Text] [PDF] A. Shafqat, L. H. Einhorn, N. Hanna, G. W. Sledge, A. Hanna, B. E. Juliar, P. Monahan, and S. Bhatia Screening studies for fatigue and laboratory correlates in cancer patients undergoing treatment{dagger} Ann. Onc., September 1, 2005; 16(9): 1545 - 1550. [Abstract] [Full Text] [PDF] R. A. Mesa, D. P. Steensma, C. Y. Li, A. Hoering, H. Powell, and A. Tefferi Phase II Study of the Combination of Low-Dose Thalidomide, Prednisone, and Etanercept ("PET regimen") in the Treatment of Anemia, Splenomegaly, and Constitutional Symptoms Associated with Myelofibrosis with Myeloid Metaplasia (MMM). Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 1520 - 1520. [Abstract] R. T. Silver Myelofibrosis: Thalidomide Finds a New Disease Mayo Clin. Proc., July 1, 2004; 79(7): 857 - 858. [PDF] R. A. Mesa, M. A. Elliott, G. Schroeder, and A. Tefferi Durable Responses to Thalidomide-Based Drug Therapy for Myelofibrosis With Myeloid Metaplasia Mayo Clin. Proc., July 1, 2004; 79(7): 883 - 889. [Abstract] [PDF] S. O'Brien, A. Tefferi, and P. Valent Chronic Myelogenous Leukemia and Myeloproliferative Disease Hematology, January 1, 2004; 2004(1): 146 - 162. [Abstract] [Full Text] [PDF] Y. Menon, E. Cucurull, and L. R. Espinoza Pancytopenia in a patient with scleroderma treated with infliximab Rheumatology, October 1, 2003; 42(10): 1273 - 1274. [Full Text] [PDF] A. Tefferi The Forgotten Myeloproliferative Disorder: Myeloid Metaplasia Oncologist, June 1, 2003; 8(3): 225 - 231. [Abstract] [Full Text] [PDF] R. A. Mesa, D. P. Steensma, A. Pardanani, C.-Y. Li, M. Elliott, S. H. Kaufmann, G. Wiseman, L. A. Gray, G. Schroeder, T. Reeder, et al. A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia Blood, April 1, 2003; 101(7): 2534 - 2541. [Abstract] [Full Text] [PDF] A. Tefferi, R. A. Mesa, L. A. Gray, D. P. Steensma, J. K. Camoriano, M. A. Elliott, A. Pardanani, S. M. Ansell, T. G. Call, G. Colon-Otero, et al. Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia Blood, May 15, 2002; 99(10): 3854 - 3856. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020