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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gris, J.-C. Articles by Marès, P. Search for Related Content PubMed PubMed Citation Articles by Gris, J.-C. Articles by Marès, P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2002, Vol. 99, No. 7, pp. 2606-2608 BRIEF REPORT High frequency of protein Z deficiency in patients with unexplained early fetal loss Jean-Christophe Gris, Isabelle Quéré, Hervé Dechaud, Eric Mercier, Caroline Pinçon, Médéric Hoffet, Marc Vasse, and Pierre Marès From the Laboratoires d'Hématologie, U.F.R. des sciences pharmaceutiques et biologiques de Montpellier, Centres Hospitaliers Universitaires de Nîmes et de Rouen; Département de Gynécologie et Obstétrique, Hôpital Caremeau, Nîmes, France. The protein Z-protein Z-dependent inhibitor complex is a factor Xa inhibitor. Protein Z deficiencies have recently been described in patients with ischemic stroke. As placenta infarction leads to poor pregnancy outcome, we studied protein Z plasma concentrations in nonthrombotic, nonthrombophilic consecutive patients with unexplained pregnancy wastage. A significant amount of protein Z deficiencies was only found in the early fetal loss group (< 1 mg/L; 44 of 200, P < 104) and mainly in the case of fetal demise between the beginning of the 10th and the end of the 15th week of gestation (odds ratio, 6.7 [3.1-14.8], P < 103). These deficiencies were not due to partial vitamin K1 deficiency, and at least some of them were constitutional ones. In women, protein Z deficiency may induce an enhanced risk of severe placental insufficiency soon after the connection of maternal and fetal circulations. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Monien, O. Kadecki, S. Baumgarten, A. Salama, T. Dorner, and H. Kiesewetter Use of Heparin in Women With Early and Late Miscarriages With and Without Thrombophilia Clinical and Applied Thrombosis/Hemostasis, December 1, 2009; 15(6): 636 - 644. [Abstract] [PDF] U. Nowak-Gottl, B. Frohlich, S. Thedieck, A. Huge, and M. Stoll Association of the protein Z ATG haplotype with symptomatic nonvascular stroke or thromboembolism in white children: a family-based cohort study Blood, March 5, 2009; 113(10): 2336 - 2341. [Abstract] [Full Text] [PDF] J. Zhang, Y. Tu, L. Lu, N. Lasky, and G. J. Broze Jr Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency Blood, May 15, 2008; 111(10): 4973 - 4978. [Abstract] [Full Text] [PDF] M. J. Heeb, K. M. Cabral, and L. Ruan Down-regulation of Factor IXa in the Factor Xase Complex by Protein Z-dependent Protease Inhibitor J. Biol. Chem., October 7, 2005; 280(40): 33819 - 33825. [Abstract] [Full Text] [PDF] M. Souri, S. Koseki-Kuno, H. Iwata, B. Kemkes-Matthes, and A. Ichinose A naturally occurring E30Q mutation in the Gla domain of protein Z causes its impaired secretion and subsequent deficiency Blood, April 15, 2005; 105(8): 3149 - 3154. [Abstract] [Full Text] [PDF] M. Bern Observations on Possible Effects of Daily Vitamin K Replacement, Especially Upon Warfarin Therapy JPEN J Parenter Enteral Nutr, November 1, 2004; 28(6): 388 - 398. [Abstract] [Full Text] [PDF] N. Ayoub, G. Esposito, S. Barete, C. Soria, J.-C. Piette, and C. Frances Protein Z Deficiency in Antiphospholipid-Negative Sneddon's Syndrome Stroke, June 1, 2004; 35(6): 1329 - 1332. [Abstract] [Full Text] [PDF] J.-C. Gris, E. Mercier, I. Quere, G. Lavigne-Lissalde, E. Cochery-Nouvellon, M. Hoffet, S. Ripart-Neveu, M.-L. Tailland, M. Dauzat, and P. Mares Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder Blood, May 15, 2004; 103(10): 3695 - 3699. [Abstract] [Full Text] [PDF] C. Lichy, S. Kropp, T. Dong-Si, J. Genius, T. Dolan, T. Hampe, F. Stoll, K. Reuner, C. Grond-Ginsbach, and A. Grau A Common Polymorphism of the Protein Z Gene Is Associated With Protein Z Plasma Levels and With Risk of Cerebral Ischemia in the Young Stroke, January 1, 2004; 35(1): 40 - 45. [Abstract] [Full Text] [PDF] J.-C. Gris, C. Amadio, E. Mercier, G. Lavigne-Lissalde, H. Dechaud, M. Hoffet, I. Quere, J. Amiral, M. Dauzat, and P. Mares Anti-protein Z antibodies in women with pathologic pregnancies Blood, June 15, 2003; 101(12): 4850 - 4852. [Abstract] [Full Text] [PDF]

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