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Blood, 1 April 2002, Vol. 99, No. 7, pp. 2617-2619
BRIEF REPORT
Expression of cyclic adenosine monophosphate response-element
binding protein in acute leukemia
Heather N. Crans-Vargas,
Elliot M. Landaw,
Smita Bhatia,
George Sandusky,
Theodore B. Moore, and
Kathleen
M. Sakamoto
From the Department of Pediatrics, Division of
Hematology-Oncology, Gwynne-Hazen Cherry Memorial Laboratories, and
Mattel Children's Hospital at University of California Los Angeles
(UCLA); the Department of Pathology, UCLA School of Medicine and
Jonsson Comprehensive Cancer Center; the Department of Biomathematics,
UCLA School of Medicine; the Department of Pediatrics, Division of
Hematology-Oncology, City of Hope National Medical Center, Duarte, CA;
and Eli Lilly Research Laboratories, Indianapolis, IN.
Cyclic adenosine monophosphate response-element binding protein
(CREB) is a nuclear protein that regulates expression of genes that
control cell proliferation, differentiation, and survival. To analyze
CREB expression in leukemia cells, we conducted Western blot analysis
of bone marrow cells obtained from patients with acute lymphoblastic
leukemia, patients with acute myeloid leukemia, and patients without
active leukemia. CREB was expressed at a higher frequency in bone
marrow cells from patients with acute lymphoid or myeloid leukemia than
in patients with leukemia remission or without leukemia. Our results
indicate that CREB expression could be a useful marker for leukemia in
patients with acute disease and suggest a role for CREB in leukemogenesis.
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