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Blood, 15 April 2002, Vol. 99, No. 8, pp. 2662-2669
PLENARY PAPER
IRTAs: a new family of immunoglobulinlike receptors
differentially expressed in B cells
Ira Miller,
Georgia Hatzivassiliou,
Giorgio Cattoretti,
Cathy Mendelsohn, and
Riccardo Dalla-Favera
From the Institute of Cancer Genetics and the
Departments of Pathology and of Genetics and Development, Columbia
University, New York, NY.
The IRTA1 and IRTA2 genes encode
immunoglobulinlike cell surface receptors expressed in B cells and
involved in chromosome 1q21 translocations in B-cell malignancy. We
have now characterized and comparatively analyzed the structure and
expression pattern of the entire family of IRTA genes, which includes 5 members contiguously located on chromosome 1q21. The IRTA messenger
RNAs are expressed predominantly in the B-cell lineage within discrete
B-cell compartments: IRTA1 is specific to the marginal
zone, IRTA2 and IRTA3 are found in the germinal
center light zone and in intraepithelial and interfollicular regions,
and IRTA4 and IRTA5 are expressed predominantly
in the mantle zone. All IRTA genes code for transmembrane receptors
that are closely related to Fc receptors in their most amino-terminal extracellular domains and that possess cytoplasmic domains containing ITIM (immunotyrosine inhibition motifs)- and, possibly, ITAM
(immunotyrosine activation motifs)-like motifs. These
structural features suggest that the IRTA receptors may play a role in
regulating activation of normal B cells and possibly in the development
of neoplasia.
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