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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bai, X.-F. Articles by Liu, Y. Search for Related Content PubMed PubMed Citation Articles by Bai, X.-F. Articles by Liu, Y. Related Collections Immunobiology Neoplasia Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 April 2002, Vol. 99, No. 8, pp. 2880-2889 IMMUNOBIOLOGY B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo Xue-Feng Bai, Jinqing Liu, Kenneth F. May Jr, Yong Guo, Pan Zheng, and Yang Liu From the Department of Pathology and the Comprehensive Cancer Center, Ohio State University Medical Center, Columbus. Costimulatory molecules B7-1 and B7-2 (hereby collectively called B7) interact with CD28 and CTLA4 on T cells and promote antitumor immunity. The function of B7-CTLA4 interaction in antitumor CTL response remains controversial. Here we used CD28/ and CD28+/ or CD28+/+ transgenic mice that express the T-cell receptor specific for an unmutated tumor antigen, P1A, and for tumor cells expressing a CTLA4-specific B7 mutant to evaluate the function of CD28-B7 and CTLA4-B7 interactions in induction and effector phases of antitumor immunity. We report that B7-CD28 and B7-CTLA4 interactions promote tumor rejection. However, this is achieved by distinct mechanisms. B7-CD28 interaction enhances T-cell clonal expansion, though a role for this interaction in the effector phase cannot be ruled out. In contrast, B7-CTLA4 interaction enhances the CTL-mediated destruction of tumors, but not T-cell clonal expansion. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X.-F. Bai, J.-Q. Liu, P. S. Joshi, L. Wang, L. Yin, J. Labanowska, N. Heerema, P. Zheng, and Y. Liu Different Lineages of P1A-Expressing Cancer Cells Use Divergent Modes of Immune Evasion for T-Cell Adoptive Therapy Cancer Res., August 15, 2006; 66(16): 8241 - 8249. [Abstract] [Full Text] [PDF] O. Li, X. Chang, H. Zhang, E. Kocak, C. Ding, P. Zheng, and Y. Liu Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts J. Exp. Med., July 10, 2006; 203(7): 1713 - 1720. [Abstract] [Full Text] [PDF] I. Tirapu, E. Huarte, C. Guiducci, A. Arina, M. Zaratiegui, O. Murillo, A. Gonzalez, C. Berasain, P. Berraondo, P. Fortes, et al. Low Surface Expression of B7-1 (CD80) Is an Immunoescape Mechanism of Colon Carcinoma Cancer Res., February 15, 2006; 66(4): 2442 - 2450. [Abstract] [Full Text] [PDF] J.-X. Gao, X. Chang, X. Zheng, J. Wen, L. Yin, P. Du, P. Zheng, and Y. Liu A new role for CD28 in the survival of autoreactive T cells in the periphery after chronic exposure to autoantigen Int. Immunol., October 1, 2004; 16(10): 1403 - 1409. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020