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Blood, 15 April 2002, Vol. 99, No. 8, pp. 3057-3059

BRIEF REPORT

High-dose therapy and autologous blood stem cell transplantation in POEMS syndrome

Arnaud Jaccard, Bruno Royer, Dominique Bordessoule, Jean-Claude Brouet, and Jean-Paul Fermand

From the Hematology Unit, Centre Hospitalier Universitaire, Limoges, France, and Immuno-Hematology Unit, Hôpital Saint-Louis, Paris, France.

We treated 5 patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and multifocal bone lesions or diffuse bone marrow plasmacytic infiltration with high-dose therapy (HDT) and autologous blood stem cell transplantation. In all cases, the treatment produced remission of plasma cell proliferation associated with marked improvement in the patients' performance status, neurologic symptoms, and other manifestations of the syndrome. HDT with stem cell support should be investigated further as a therapeutic option in patients with POEMS syndrome and disseminated plasma cell dyscrasia.

© 2002 by The American Society of Hematology.
 

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Related Letter in Blood Online:

Long-term follow-up on a patient with incomplete POEMS syndrome undergoing high-dose therapy and autologous blood stem cell transplantation
Anne Wiesmann, Robert Weissert, Lothar Kanz, and Hermann Einsele
Blood 2002 100: 2679-2680. [Full Text] [PDF]



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