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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gopal, A. K. Articles by Press, O. W. Search for Related Content PubMed PubMed Citation Articles by Gopal, A. K. Articles by Press, O. W. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 May 2002, Vol. 99, No. 9, pp. 3158-3162 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma Ajay K. Gopal, Joseph G. Rajendran, Stephen H. Petersdorf, David G. Maloney, Janet F. Eary, Brent L. Wood, Theodore A. Gooley, Sharon A. Bush, Lawrence D. Durack, Paul J. Martin, Dana C. Matthews, Frederick R. Appelbaum, Irwin D. Bernstein, and Oliver W. Press From the Clinical Research Division, Fred Hutchinson Cancer Research Center, and the Department of Medicine, Division of Medical Oncology, Department of Radiology, Division of Nuclear Medicine, Department of Pathology, Department of Biostatistics, and Department of Pediatrics, University of Washington, Seattle, WA. Relapsed mantle cell lymphoma is a radiation-sensitive malignancy that is unlikely to be cured by treatment with conventional high-dose therapy and autologous stem cell transplantation. We tested the safety and efficacy of using a CD20-specific monoclonal antibody conjugated with 131I to deliver high-dose radiation selectively to all lymphoma sites. Patients with relapsed or refractory mantle cell lymphoma received infusions of 131I-labeled CD20-specific monoclonal antibody (Tositumomab). The antibody dose was 1.7 mg/kg body weight, and the amount of 131I was calibrated to deliver 20 to 25 Gy to vital normal organs. This treatment was followed 10 days later by administration of high-dose etoposide (30-60 mg/kg), cyclophosphamide (60-100 mg/kg), and infusion of cryopreserved autologous stem cells. The 16 patients in this study had received a median of 3 prior treatments, and 7 had chemotherapy-resistant disease. The median dose of 131I was 510 mCi (18.87 GBq). There were no therapy-related deaths. Among the 11 patients with conventionally measurable disease at the time of treatment, the respective complete and overall response rates were 91% and 100%. Fifteen patients remain alive, and 12 have had no progression of lymphoma at 6 to 57 months from transplantation and 16 to 97 months from diagnosis. Overall survival at 3 years from transplantation is estimated at 93%, and progression-free survival is estimated at 61%. High-dose treatment with 131I-Tositumomab, etoposide, and cyclophosphamide results in a high remission rate and may provide long-term disease-free survival for patients with relapsed or refractory mantle cell lymphoma. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. R. Appelbaum Hematopoietic Cell Transplantation for Non-Hodgkin's Lymphoma: Yesterday, Today, and Tomorrow J. Clin. Oncol., June 20, 2008; 26(18): 2927 - 2929. [Full Text] [PDF] J. G. Rajendran, A. K. Gopal, D. R. Fisher, L. D. Durack, T. A. Gooley, and O. W. Press Myeloablative 131I-Tositumomab Radioimmunotherapy in Treating Non-Hodgkin's Lymphoma: Comparison of Dosimetry Based on Whole-Body Retention and Dose to Critical Organ Receiving the Highest Dose J. Nucl. 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Drach Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma Blood, October 15, 2004; 104(8): 2269 - 2271. [Abstract] [Full Text] [PDF] J. G. Rajendran, D. R. Fisher, A. K. Gopal, L. D. Durack, O. W. Press, and J. F. Eary High-Dose 131I-Tositumomab (Anti-CD20) Radioimmunotherapy for Non-Hodgkin's Lymphoma: Adjusting Radiation Absorbed Dose to Actual Organ Volumes J. Nucl. Med., June 1, 2004; 45(6): 1059 - 1064. [Abstract] [Full Text] [PDF] M. Bendandi, S. A. Pileri, and P. L. Zinzani Challenging paradigms in lymphoma treatment Ann. Onc., May 1, 2004; 15(5): 703 - 711. [Full Text] [PDF] I. F. Khouri, M.-S. Lee, R. M. Saliba, G. Jun, L. Fayad, A. Younes, B. Pro, S. Acholonu, P. McLaughlin, R. L. Katz, et al. Nonablative Allogeneic Stem-Cell Transplantation for Advanced/Recurrent Mantle-Cell Lymphoma J. Clin. Oncol., December 1, 2003; 21(23): 4407 - 4412. [Abstract] [Full Text] [PDF] H. A. Leitch, R. D. Gascoyne, M. Chhanabhai, N. J. Voss, R. Klasa, and J. M. Connors Limited-stage mantle-cell lymphoma Ann. Onc., October 1, 2003; 14(10): 1555 - 1561. [Abstract] [Full Text] [PDF] D. V. Gold, K. Schutsky, D. Modrak, and T. M. Cardillo Low-Dose Radioimmunotherapy (90Y-PAM4) Combined with Gemcitabine for the Treatment of Experimental Pancreatic Cancer Clin. Cancer Res., September 1, 2003; 9(10): 3929S - 3937. [Abstract] [Full Text] [PDF] A. M. Gianni, M. Magni, M. Martelli, M. Di Nicola, C. Carlo-Stella, S. Pilotti, A. Rambaldi, S. Cortelazzo, C. Patti, G. Parvis, et al. Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen) Blood, July 15, 2003; 102(2): 749 - 755. [Abstract] [Full Text] [PDF]

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