SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Montoya, M. Articles by Tough, D. F. Search for Related Content PubMed PubMed Citation Articles by Montoya, M. Articles by Tough, D. F. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 May 2002, Vol. 99, No. 9, pp. 3263-3271 IMMUNOBIOLOGY Type I interferons produced by dendritic cells promote their phenotypic and functional activation Maria Montoya, Giovanna Schiavoni, Fabrizio Mattei, Ion Gresser, Filippo Belardelli, Persephone Borrow, and David F. Tough From the Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, United Kingdom; Laboratory of Virology, Istituto Superiore di Sanità, Rome, Italy; and INSERM U255-Institut Curie, Paris, France. Resting dendritic cells (DCs) are resident in most tissues and can be activated by environmental stimuli to mature into potent antigen-presenting cells. One important stimulus for DC activation is infection; DCs can be triggered through receptors that recognize microbial components directly or by contact with infection-induced cytokines. We show here that murine DCs undergo phenotypic maturation upon exposure to type I interferons (type I IFNs) in vivo or in vitro. Moreover, DCs either derived from bone marrow cells in vitro or isolated from the spleens of normal animals express IFN- and IFN-, suggesting that type I IFNs can act in an autocrine manner to activate DCs. Consistent with this idea, the ability to respond to type I IFN was required for the generation of fully activated DCs from bone marrow precursors, as DCs derived from the bone marrow of mice lacking a functional receptor for type I IFN had reduced expression of costimulatory and adhesion molecules and a diminished ability to stimulate naive T-cell proliferation compared with DCs derived from control bone marrow. Furthermore, the addition of neutralizing anti-IFN-/ antibody to purified splenic DCs in vitro partially blocked the "spontaneous" activation of these cells, inhibiting the up-regulation of costimulatory molecules, secretion of IFN-, and T-cell stimulatory activity. These results show that DCs both secrete and respond to type I IFN, identifying type I interferons as autocrine DC activators. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Martinez-Sobrido, S. Emonet, P. Giannakas, B. Cubitt, A. Garcia-Sastre, and J. C. de la Torre Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus J. Virol., November 1, 2009; 83(21): 11330 - 11340. [Abstract] [Full Text] [PDF] H. Agrawal, N. Jacob, E. Carreras, S. Bajana, C. Putterman, S. Turner, B. Neas, A. Mathian, M. N. Koss, W. Stohl, et al. Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease J. Immunol., November 1, 2009; 183(9): 6021 - 6029. [Abstract] [Full Text] [PDF] N. Zietara, M. Lyszkiewicz, N. Gekara, J. Puchalka, V. A. P. M. Dos Santos, C. R. Hunt, T. K. Pandita, S. Lienenklaus, and S. Weiss Absence of IFN-{beta} Impairs Antigen Presentation Capacity of Splenic Dendritic Cells via Down-Regulation of Heat Shock Protein 70 J. Immunol., July 15, 2009; 183(2): 1099 - 1109. [Abstract] [Full Text] [PDF] M. P. Longhi, C. Trumpfheller, J. Idoyaga, M. Caskey, I. Matos, C. Kluger, A. M. Salazar, M. Colonna, and R. M. Steinman Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant J. Exp. Med., July 6, 2009; 206(7): 1589 - 1602. [Abstract] [Full Text] [PDF] A. Mosa, C. Trumstedt, E. Eriksson, O. Soehnlein, F. Heuts, K. Janik, A. Klos, O. Dittrich-Breiholz, M. Kracht, A. Hidmark, et al. Nonhematopoietic Cells Control the Outcome of Infection with Listeria monocytogenes in a Nucleotide Oligomerization Domain 1-Dependent Manner Infect. Immun., July 1, 2009; 77(7): 2908 - 2918. [Abstract] [Full Text] [PDF] V. A. K. Rathinam, D. M. Appledorn, K. A. Hoag, A. Amalfitano, and L. S. Mansfield Campylobacter jejuni-Induced Activation of Dendritic Cells Involves Cooperative Signaling through Toll-Like Receptor 4 (TLR4)-MyD88 and TLR4-TRIF Axes Infect. Immun., June 1, 2009; 77(6): 2499 - 2507. [Abstract] [Full Text] [PDF] C. D. Conrady, M. Thapa, T. Wuest, and D. J. J. Carr Loss of Mandibular Lymph Node Integrity Is Associated with an Increase in Sensitivity to HSV-1 Infection in CD118-Deficient Mice J. Immunol., March 15, 2009; 182(6): 3678 - 3687. [Abstract] [Full Text] [PDF] P. Bochtler, A. Kroger, R. Schirmbeck, and J. Reimann Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells J. Immunol., August 1, 2008; 181(3): 1633 - 1643. [Abstract] [Full Text] [PDF] C. Biondo, A. Midiri, M. Gambuzza, E. Gerace, M. Falduto, R. Galbo, A. Bellantoni, C. Beninati, G. Teti, T. Leanderson, et al. IFN-{alpha}/{beta} Signaling Is Required for Polarization of Cytokine Responses toward a Protective Type 1 Pattern during Experimental Cryptococcosis J. Immunol., July 1, 2008; 181(1): 566 - 573. [Abstract] [Full Text] [PDF] F. Pascale, V. Contreras, M. Bonneau, A. Courbet, S. Chilmonczyk, C. Bevilacqua, M. Eparaud, V. Niborski, S. Riffault, A.-M. Balazuc, et al. Plasmacytoid Dendritic Cells Migrate in Afferent Skin Lymph J. Immunol., May 1, 2008; 180(9): 5963 - 5972. [Abstract] [Full Text] [PDF] L. Adalid-Peralta, V. Godot, C. Colin, R. Krzysiek, T. Tran, P. Poignard, A. Venet, A. Hosmalin, P. Lebon, C. Rouzioux, et al. Stimulation of the primary anti-HIV antibody response by IFN-{alpha} in patients with acute HIV-1 infection J. Leukoc. Biol., April 1, 2008; 83(4): 1060 - 1067. [Abstract] [Full Text] [PDF] M. A. Nolte, S. LeibundGut-Landmann, O. Joffre, and C. R. e Sousa Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo J. Exp. Med., June 11, 2007; 204(6): 1487 - 1501. [Abstract] [Full Text] [PDF] E. M. Behrens, U. Sriram, D. K. Shivers, M. Gallucci, Z. Ma, T. H. Finkel, and S. Gallucci Complement Receptor 3 Ligation of Dendritic Cells Suppresses Their Stimulatory Capacity J. Immunol., May 15, 2007; 178(10): 6268 - 6279. [Abstract] [Full Text] [PDF] B. D. Brown, G. Sitia, A. Annoni, E. Hauben, L. S. Sergi, A. Zingale, M. G. Roncarolo, L. G. Guidotti, and L. Naldini In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance Blood, April 1, 2007; 109(7): 2797 - 2805. [Abstract] [Full Text] [PDF] I. Douagi, G. M. McInerney, A. S. Hidmark, V. Miriallis, K. Johansen, L. Svensson, and G. B. Karlsson Hedestam Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts J. Virol., March 15, 2007; 81(6): 2758 - 2768. [Abstract] [Full Text] [PDF] G. Mancuso, A. Midiri, C. Biondo, C. Beninati, S. Zummo, R. Galbo, F. Tomasello, M. Gambuzza, G. Macri, A. Ruggeri, et al. Type I IFN Signaling Is Crucial for Host Resistance against Different Species of Pathogenic Bacteria J. Immunol., March 1, 2007; 178(5): 3126 - 3133. [Abstract] [Full Text] [PDF] B. Dauber, J. Schneider, and T. Wolff Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon J. Virol., December 1, 2006; 80(23): 11667 - 11677. [Abstract] [Full Text] [PDF] K. S. Bahjat, W. Liu, E. E. Lemmens, S. P. Schoenberger, D. A. Portnoy, T. W. Dubensky Jr., and D. G. Brockstedt Cytosolic Entry Controls CD8+-T-Cell Potency during Bacterial Infection Infect. Immun., November 1, 2006; 74(11): 6387 - 6397. [Abstract] [Full Text] [PDF] R. Romieu-Mourez, M. Solis, A. Nardin, D. Goubau, V. Baron-Bodo, R. Lin, B. Massie, M. Salcedo, and J. Hiscott Distinct Roles for IFN Regulatory Factor (IRF)-3 and IRF-7 in the Activation of Antitumor Properties of Human Macrophages Cancer Res., November 1, 2006; 66(21): 10576 - 10585. [Abstract] [Full Text] [PDF] S. McBride, K. Hoebe, P. Georgel, and E. Janssen Cell-Associated Double-Stranded RNA Enhances Antitumor Activity through the Production of Type I IFN J. Immunol., November 1, 2006; 177(9): 6122 - 6128. [Abstract] [Full Text] [PDF] J. Louten, N. van Rooijen, and C. A. Biron Type 1 IFN Deficiency in the Absence of Normal Splenic Architecture during Lymphocytic Choriomeningitis Virus Infection. J. Immunol., September 1, 2006; 177(5): 3266 - 3272. [Abstract] [Full Text] [PDF] T. H. Harris, N. M. Cooney, J. M. Mansfield, and D. M. Paulnock Signal transduction, gene transcription, and cytokine production triggered in macrophages by exposure to trypanosome DNA. Infect. Immun., August 1, 2006; 74(8): 4530 - 4537. [Abstract] [Full Text] [PDF] A. S. Hidmark, E. K. L. Nordstrom, P. Dosenovic, M. N. E. Forsell, P. Liljestrom, and G. B. Karlsson Hedestam Humoral Responses against Coimmunized Protein Antigen but Not against Alphavirus-Encoded Antigens Require Alpha/Beta Interferon Signaling J. Virol., July 15, 2006; 80(14): 7100 - 7110. [Abstract] [Full Text] [PDF] L. A. Minns, L. C. Menard, D. M. Foureau, S. Darche, C. Ronet, D. W. Mielcarz, D. Buzoni-Gatel, and L. H. Kasper TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response following Oral Infection of Toxoplasma gondii. J. Immunol., June 15, 2006; 176(12): 7589 - 7597. [Abstract] [Full Text] [PDF] A. Sato, M. Ohtsuki, M. Hata, E. Kobayashi, and T. Murakami Antitumor Activity of IFN-{lambda} in Murine Tumor Models. J. Immunol., June 15, 2006; 176(12): 7686 - 7694. [Abstract] [Full Text] [PDF] M. Severa, M. E. Remoli, E. Giacomini, J. Ragimbeau, R. Lande, G. Uze, S. Pellegrini, and E. M. Coccia Differential responsiveness to IFN-{alpha} and IFN-{beta} of human mature DC through modulation of IFNAR expression J. Leukoc. Biol., June 1, 2006; 79(6): 1286 - 1294. [Abstract] [Full Text] [PDF] A. G. Rothfuchs, C. Trumstedt, F. Mattei, G. Schiavoni, A. Hidmark, H. Wigzell, and M. E. Rottenberg STAT1 Regulates IFN-{alpha}beta- and IFN-{gamma}-Dependent Control of Infection with Chlamydia pneumoniae by Nonhemopoietic Cells. J. Immunol., June 1, 2006; 176(11): 6982 - 6990. [Abstract] [Full Text] [PDF] C. B. Lopez, J. S. Yount, T. Hermesh, and T. M. Moran Sendai Virus Infection Induces Efficient Adaptive Immunity Independently of Type I Interferons J. Virol., May 1, 2006; 80(9): 4538 - 4545. [Abstract] [Full Text] [PDF] U. Yrlid, S. W. F. Milling, J. L. Miller, S. Cartland, C. D. Jenkins, and G. G. MacPherson Regulation of Intestinal Dendritic Cell Migration and Activation by Plasmacytoid Dendritic Cells, TNF-{alpha} and Type 1 IFNs after Feeding a TLR7/8 Ligand J. Immunol., May 1, 2006; 176(9): 5205 - 5212. [Abstract] [Full Text] [PDF] N. Gerlach, S. Schimmer, S. Weiss, U. Kalinke, and U. Dittmer Effects of type I interferons on friend retrovirus infection. J. Virol., April 1, 2006; 80(7): 3438 - 3444. [Abstract] [Full Text] [PDF] G. Schlecht, J. Mouries, M. Poitrasson-Riviere, C. Leclerc, and G. Dadaglio Purification of splenic dendritic cells induces maturation and capacity to stimulate Th1 response in vivo Int. Immunol., March 1, 2006; 18(3): 445 - 452. [Abstract] [Full Text] [PDF] M. J. Edwards, O. Buchatska, M. Ashton, M. Montoya, Q. D. Bickle, and P. Borrow Reciprocal Immunomodulation in a Schistosome and Hepatotropic Virus Coinfection Model J. Immunol., November 15, 2005; 175(10): 6275 - 6285. [Abstract] [Full Text] [PDF] M. Sundquist and M. J. Wick TNF-{alpha}-Dependent and -Independent Maturation of Dendritic Cells and Recruited CD11cintCD11b+ Cells during Oral Salmonella Infection J. Immunol., September 1, 2005; 175(5): 3287 - 3298. [Abstract] [Full Text] [PDF] A. S. Hidmark, G. M. McInerney, E. K. L. Nordstrom, I. Douagi, K. M. Werner, P. Liljestrom, and G. B. K. Hedestam Early Alpha/Beta Interferon Production by Myeloid Dendritic Cells in Response to UV-Inactivated Virus Requires Viral Entry and Interferon Regulatory Factor 3 but Not MyD88 J. Virol., August 15, 2005; 79(16): 10376 - 10385. [Abstract] [Full Text] [PDF] N. Kuwashima, F. Nishimura, J. Eguchi, H. Sato, M. Hatano, T. Tsugawa, T. Sakaida, J. E. Dusak, W. K. Fellows-Mayle, G. D. Papworth, et al. Delivery of Dendritic Cells Engineered to Secrete IFN-{alpha} into Central Nervous System Tumors Enhances the Efficacy of Peripheral Tumor Cell Vaccines: Dependence on Apoptotic Pathways J. Immunol., August 15, 2005; 175(4): 2730 - 2740. [Abstract] [Full Text] [PDF] S. S. Pejawar, G. D. Parks, and M. A. Alexander-Miller Abortive versus Productive Viral Infection of Dendritic Cells with a Paramyxovirus Results in Differential Upregulation of Select Costimulatory Molecules J. Virol., June 15, 2005; 79(12): 7544 - 7557. [Abstract] [Full Text] [PDF] E. M. Bautista, G. S. Ferman, D. Gregg, M. C. S. Brum, M. J. Grubman, and W. T. Golde Constitutive Expression of Alpha Interferon by Skin Dendritic Cells Confers Resistance to Infection by Foot-and-Mouth Disease Virus J. Virol., April 15, 2005; 79(8): 4838 - 4847. [Abstract] [Full Text] [PDF] C. Asselin-Paturel, G. Brizard, K. Chemin, A. Boonstra, A. O'Garra, A. Vicari, and G. Trinchieri Type I interferon dependence of plasmacytoid dendritic cell activation and migration J. Exp. Med., April 4, 2005; 201(7): 1157 - 1167. [Abstract] [Full Text] [PDF] S. Richardson, J. B. Budgin, J. M. Junkins-Hopkins, C. C. Vittorio, J. Lee, W. T. Miller Jr, A. H. Rook, and E. J. Kim Low-Dose Bexarotene and Low-Dose Interferon Alfa-2b for Adult T-Cell Leukemia/Lymphoma Associated With Human T-Lymphotropic Virus 1 Arch Dermatol, March 1, 2005; 141(3): 301 - 304. [Full Text] [PDF] D. R. Palmer, P. Sun, C. Celluzzi, J. Bisbing, S. Pang, W. Sun, M. A. Marovich, and T. Burgess Differential Effects of Dengue Virus on Infected and Bystander Dendritic Cells J. Virol., February 15, 2005; 79(4): 2432 - 2439. [Abstract] [Full Text] [PDF] M. Montoya, M. J. Edwards, D. M. Reid, and P. Borrow Rapid Activation of Spleen Dendritic Cell Subsets following Lymphocytic Choriomeningitis Virus Infection of Mice: Analysis of the Involvement of Type 1 IFN J. Immunol., February 15, 2005; 174(4): 1851 - 1861. [Abstract] [Full Text] [PDF] K. McKenna, A.-S. Beignon, and N. Bhardwaj Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity J. Virol., January 1, 2005; 79(1): 17 - 27. [Full Text] [PDF] M. Wysocka, B. M. Benoit, S. Newton, L. Azzoni, L. J. Montaner, and A. H. Rook Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15 Blood, December 15, 2004; 104(13): 4142 - 4149. [Abstract] [Full Text] [PDF] G. Schlecht, S. Garcia, N. Escriou, A. A. Freitas, C. Leclerc, and G. Dadaglio Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation Blood, September 15, 2004; 104(6): 1808 - 1815. [Abstract] [Full Text] [PDF] G. B. Lesinski, S. V. Kondadasula, T. Crespin, L. Shen, K. Kendra, M. Walker, and W. E. Carson III Multiparametric Flow Cytometric Analysis of Inter-Patient Variation in STAT1 Phosphorylation Following Interferon Alfa Immunotherapy J Natl Cancer Inst, September 1, 2004; 96(17): 1331 - 1342. [Abstract] [Full Text] [PDF] F. Palamara, S. Meindl, M. Holcmann, P. Luhrs, G. Stingl, and M. Sibilia Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod J. Immunol., September 1, 2004; 173(5): 3051 - 3061. [Abstract] [Full Text] [PDF] A. S. McKee, F. Dzierszinski, M. Boes, D. S. Roos, and E. J. Pearce Functional Inactivation of Immature Dendritic Cells by the Intracellular Parasite Toxoplasma gondii J. Immunol., August 15, 2004; 173(4): 2632 - 2640. [Abstract] [Full Text] [PDF] K. L. Brzoza, A. B. Rockel, and E. M. Hiltbold Cytoplasmic Entry of Listeria monocytogenes Enhances Dendritic Cell Maturation and T Cell Differentiation and Function J. Immunol., August 15, 2004; 173(4): 2641 - 2651. [Abstract] [Full Text] [PDF] G. Schiavoni, C. Mauri, D. Carlei, F. Belardelli, M. Castellani Pastoris, and E. Proietti Type I IFN Protects Permissive Macrophages from Legionella pneumophila Infection through an IFN-{gamma}-Independent Pathway J. Immunol., July 15, 2004; 173(2): 1266 - 1275. [Abstract] [Full Text] [PDF] S. Salek-Ardakani, S. A. Lyons, and J. R. Arrand Epstein-Barr Virus Promotes Human Monocyte Survival and Maturation through a Paracrine Induction of IFN-{alpha} J. Immunol., July 1, 2004; 173(1): 321 - 331. [Abstract] [Full Text] [PDF] M. Franchini, H. Hefti, S. Vollstedt, B. Glanzmann, M. Riesen, M. Ackermann, P. Chaplin, K. Shortman, and M. Suter Dendritic Cells from Mice Neonatally Vaccinated with Modified Vaccinia Virus Ankara Transfer Resistance against Herpes Simplex Virus Type I to Naive One-Week-Old Mice J. Immunol., May 15, 2004; 172(10): 6304 - 6312. [Abstract] [Full Text] [PDF] D. Tosi, R. Valenti, A. Cova, G. Sovena, V. Huber, L. Pilla, F. Arienti, F. Belardelli, G. Parmiani, and L. Rivoltini Role of Cross-Talk between IFN-{alpha}-Induced Monocyte-Derived Dendritic Cells and NK Cells in Priming CD8+ T Cell Responses against Human Tumor Antigens J. Immunol., May 1, 2004; 172(9): 5363 - 5370. [Abstract] [Full Text] [PDF] K. Al-khatib, B. R. G. Williams, R. H. Silverman, W. Halford, and D. J. J. Carr Distinctive Roles for 2',5'-Oligoadenylate Synthetases and Double-Stranded RNA-Dependent Protein Kinase R in the In Vivo Antiviral Effect of an Adenoviral Vector Expressing Murine IFN-{beta} J. Immunol., May 1, 2004; 172(9): 5638 - 5647. [Abstract] [Full Text] [PDF] E. Ichikawa, S. Hida, Y. Omatsu, S. Shimoyama, K. Takahara, S. Miyagawa, K. Inaba, and S. Taki Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2 PNAS, March 16, 2004; 101(11): 3909 - 3914. [Abstract] [Full Text] [PDF] G. Schiavoni, F. Mattei, P. Borghi, P. Sestili, M. Venditti, H. C. Morse III, F. Belardelli, and L. Gabriele ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells Blood, March 15, 2004; 103(6): 2221 - 2228. [Abstract] [Full Text] [PDF] N. Chaput, N. E. C. Schartz, F. Andre, J. Taieb, S. Novault, P. Bonnaventure, N. Aubert, J. Bernard, F. Lemonnier, M. Merad, et al. Exosomes as Potent Cell-Free Peptide-Based Vaccine. II. Exosomes in CpG Adjuvants Efficiently Prime Naive Tc1 Lymphocytes Leading to Tumor Rejection J. Immunol., February 15, 2004; 172(4): 2137 - 2146. [Abstract] [Full Text] [PDF] L. Gabriele, P. Borghi, C. Rozera, P. Sestili, M. Andreotti, A. Guarini, E. Montefusco, R. Foa, and F. Belardelli IFN-{alpha} promotes the rapid differentiation of monocytes from patients with chronic myeloid leukemia into activated dendritic cells tuned to undergo full maturation after LPS treatment Blood, February 1, 2004; 103(3): 980 - 987. [Abstract] [Full Text] [PDF] V. van Pesch and T. Michiels Characterization of Interferon-{alpha} 13, a Novel Constitutive Murine Interferon-{alpha} Subtype J. Biol. Chem., November 21, 2003; 278(47): 46321 - 46328. [Abstract] [Full Text] [PDF] J. A. Murphy, R. J. Duerst, T. J. Smith, and L. A. Morrison Herpes Simplex Virus Type 2 Virion Host Shutoff Protein Regulates Alpha/Beta Interferon but Not Adaptive Immune Responses during Primary Infection In Vivo J. Virol., September 1, 2003; 77(17): 9337 - 9345. [Abstract] [Full Text] [PDF] F. Moschella, B. Bisikirska, A. Maffei, K. P. Papadopoulos, D. Skerrett, Z. Liu, C. S. Hesdorffer, and P. E. Harris Gene Expression Profiling and Functional Activity of Human Dendritic Cells Induced with IFN-{alpha}-2b: Implications for Cancer Immunotherapy Clin. Cancer Res., June 1, 2003; 9(6): 2022 - 2031. [Abstract] [Full Text] [PDF] T. K. Means, F. Hayashi, K. D. Smith, A. Aderem, and A. D. Luster The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells J. Immunol., May 15, 2003; 170(10): 5165 - 5175. [Abstract] [Full Text] [PDF] M. Dalod, T. Hamilton, R. Salomon, T. P. Salazar-Mather, S. C. Henry, J. D. Hamilton, and C. A. Biron Dendritic Cell Responses to Early Murine Cytomegalovirus Infection: Subset Functional Specialization and Differential Regulation by Interferon {alpha}/{beta} J. Exp. Med., April 7, 2003; 197(7): 885 - 898. [Abstract] [Full Text] [PDF] P. Brawand, D. R. Fitzpatrick, B. W. Greenfield, K. Brasel, C. R. Maliszewski, and T. De Smedt Murine Plasmacytoid Pre-Dendritic Cells Generated from Flt3 Ligand-Supplemented Bone Marrow Cultures Are Immature APCs J. Immunol., December 15, 2002; 169(12): 6711 - 6719. [Abstract] [Full Text] [PDF] G. Schiavoni, F. Mattei, P. Sestili, P. Borghi, M. Venditti, H. C. Morse III, F. Belardelli, and L. Gabriele ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8{alpha}+ Dendritic Cells J. Exp. Med., December 2, 2002; 196(11): 1415 - 1425. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020