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Blood, 1 May 2002, Vol. 99, No. 9, pp. 3468-3471
BRIEF REPORT
Significance of the detection of antineutrophil antibodies in
children with chronic neutropenia
Masao Kobayashi,
Kazuhiro Nakamura,
Hiroshi Kawaguchi,
Takashi Sato,
Hirotaka Kihara,
Asako Hiraoka,
Misae Tanihiro,
Kikuyo Taniguchi,
Noboru Takata, and
Kazuhiro Ueda
From the Department of Pediatrics, Hiroshima University
School of Medicine, Hiroshima, Japan; the Department of Child Health,
Hiroshima University Graduate School of Education, Higashi-Hiroshima,
Japan; and the Division of Transfusion, Hiroshima University Hospital,
Hiroshima University School of Medicine, Hiroshima, Japan.
We evaluated the clinical characteristics of 41 children with
chronic neutropenia based on the quantitative analysis of
antineutrophil antibodies in serum by flow cytometry. According to the
strength of antineutrophil antibodies, the patients were divided into 3 groups: 12 patients presented negative antibodies, 13 patients showed
weak positive antibodies, and 16 patients showed strong positive
antibodies. No significant differences were seen in age of diagnosis,
severity of neutropenia, and infectious complications associated with
neutropenia among the 3 groups. The spontaneous resolution of
neutropenia was observed in all patients with negative antibodies and
in 22 of 29 patients with positive antibodies. The age of the recovery
of neutropenia and the duration until spontaneous resolution of
neutropenia were significantly dependent on the antibody strength at
the time of diagnosis. These results demonstrate that the
quantification of antineutrophil antibodies at the time of diagnosis
may be useful in considering the clinical course of chronic neutropenia
in childhood.
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