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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3161-3167. Prepublished online as a Blood First Edition Paper on July 20, 2006; DOI 10.1182/blood-2005-01-026690. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2005-01-026690v1 108/9/3161    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hill, D. A Articles by Rothman, N. Search for Related Content PubMed PubMed Citation Articles by Hill, D. A Articles by Rothman, N. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 13, 2006 Accepted June 26, 2006 Risk of Non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes Deirdre A Hill*, Sophia S Wang, James R Cerhan, Scott Davis, Wendy Cozen, Richard K Severson, Patricia Hartge, Sholom Wacholder, Meredith Yeager, Stephen J Chanock, and Nathaniel Rothman University of New Mexico, Albuquerque, Cancer Center and Dept of Internal Medicine Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD Mayo Clinic College of Medicine, Rochester, MN, USA and University of Iowa, Iowa City, IA, USA. Fred Hutchinson Cancer Research Center and University of Washington, Seattle Dept. Of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles Karmanos Cancer Institute and Dept. of Family Medicine, Wayne State University, Detroit, MI Core Genotyping Facility, Advanced Technology Corp, National Cancer Institute, NIH, DHHS, Gaithersbu * Corresponding author; email: dahill{at}salud.unm.edu. Chromosomal translocations, insertions, and deletions are common early events in NHL carcinogenesis, and implicated in their formation are endogenous processes involved in antigen-receptor diversification, such as V(D)J recombination. DNA repair genes respond to the double- and single-strand breaks induced by these processes, and may influence NHL etiology. We examined 34 genetic variants in 19 genes within or related to five DNA repair pathways among 1172 cases and 982 matched controls who participated in a population-based NHL study in Los Angeles, Seattle, Detroit and Iowa from 1998-2000. Cases were more likely than controls to have the RAG1 820 Arg/Arg (Odds ratio (OR) 2.7; 95% confidence interval (CI) 1.4-5.0) than Lys/Lys genotypes, with evidence of a gene dosage effect (p-trend=0.0008) and less likely to have the LIG4 (DNA Ligase IV) 9 Ile/Ile (OR 0.5; 95% CI 0.3-0.9) than Thr/Thr genotype (p-trend =0.03) in the non-homologous end joining (NHEJ)/V(D)J pathway. These NHEJ/V(D)J-related gene variants represent promising candidates for further studies of NHL etiology, and require replication in other studies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: RAG1 and BRCA2 polymorphisms in non-Hodgkin lymphoma Kathryn Scott, Peter J. Adamson, Sharon L. Barrans, Lisa J. Worrillow, Eleanor V. Willett, and James M. Allan Blood 2007 109: 5522-5523. [Full Text] [PDF] NHL and genomic variability in RAG1 and BRCA2 Deirdre A. Hill, Sophia Wang, Patricia Hartge, and Nathaniel Rothman Blood 2007 109: 5523. [Full Text] [PDF] Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study Unhee Lim, Sophia S. Wang, Patricia Hartge, Wendy Cozen, Linda E. Kelemen, Stephen Chanock, Scott Davis, Aaron Blair, Maryjean Schenk, Nathaniel Rothman, and Qing Lan Blood 2007 109: 3050-3059. [Abstract] [Full Text] [PDF]

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