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Blood, 15 July 2006, Vol. 108, No. 2, pp. 559-565. Prepublished online as a Blood First Edition Paper on March 23, 2006; DOI 10.1182/blood-2005-07-007096. This Article Full Text (PDF) All Versions of this Article: blood-2005-07-007096v1 108/2/559    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lavrik, I. N Articles by Krammer, P. H Search for Related Content PubMed PubMed Citation Articles by Lavrik, I. N Articles by Krammer, P. H Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 18, 2005 Accepted March 3, 2006 Caspase-2 is activated at the CD95 Death-Inducing Signaling complex in the course of CD95-induced apoptosis Inna N Lavrik*, Alexander Golks, Simone Baumann, and Peter H Krammer DKFZ Heidelberg DKFZ * Corresponding author; email: i.lavrik{at}dkfz.de. Caspase-2 was reported to be involved in a number of apoptotic pathways triggered by various stimuli. However, the molecular mechanism of procaspase-2 activation in the course of apoptosis remains poorly defined. In this report, we demonstrate that procaspase- 2 is recruited to the CD95 (Fas/APO-1) Death Inducing Signaling Complex (DISC) in human T and B cell lines. We show that procaspase-2 is activated at the DISC upon CD95 stimulation. Despite its presence at the DISC caspase-2 does not initiate apoptosis upon CD95 stimulation in caspase-8 deficient cell lines. Taken together, our data reveal that caspase-2 is activated at the DISC but does not play an initiating role in the CD95-induced apoptosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Fushimi, P. Ray, A. Kar, L. Wang, L. C. Sutherland, and J. Y. Wu Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5 PNAS, October 14, 2008; 105(41): 15708 - 15713. [Abstract] [Full Text] [PDF] Y. Yan, X. Su, Y. Liang, J. Zhang, C. Shi, Y. Lu, L. Gu, and L. Fu Emodin azide methyl anthraquinone derivative triggers mitochondrial-dependent cell apoptosis involving in caspase-8-mediated Bid cleavage Mol. Cancer Ther., June 1, 2008; 7(6): 1688 - 1697. [Abstract] [Full Text] [PDF] N. M. Mhaidat, Y. Wang, K. A. Kiejda, X. D. Zhang, and P. Hersey Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2 Mol. Cancer Ther., February 1, 2007; 6(2): 752 - 761. [Abstract] [Full Text] [PDF] A. K. Samraj, D. Sohn, K. Schulze-Osthoff, and I. Schmitz Loss of Caspase-9 Reveals Its Essential Role for Caspase-2 Activation and Mitochondrial Membrane Depolarization Mol. Biol. Cell, January 1, 2007; 18(1): 84 - 93. [Abstract] [Full Text] [PDF]

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