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 Blood, 15 September 2006, Vol. 108, No. 6, pp. 1857-1864.
Prepublished online as a Blood First Edition Paper on May 30, 2006; DOI 10.1182/blood-2005-10-007658.

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Submitted October 20, 2005
Accepted May 7, 2006

Adult murine hematopoiesis can proceed without {beta}1 and {beta}7 integrins

Gerd Bungartz, Sebastian Stiller, Martina Bauer, Werner Muller, Angela Schippers, Norbert Wagner, Reinhard Fassler*, and Cord Brakebusch

Max Planck Institute of Biochemistry, Dept. of Molecular Medicine, Martinsried, Germany
German Research Center for Biotechnology, Dept. of Experimental Immunology, Braunschweig, Germany
Department of Pediatrics, City Hospital of Dortmund, Dortmund, Germany
Max Planck Institute of Biochemistry, Heisenberg Group 'Regulation of Cytoskeletal Organization'

* Corresponding author; email: faessler{at}biochem.mpg.de.

The function of {alpha}4{beta}1 and {alpha}4{beta}7 integrins in hematopoiesis is controversial. While some experimental evidences suggest a crucial role for these integrins in retention and expansion of progenitor cells and lymphopoiesis, others report a less important role in hematopoiesis. Using mice with a deletion of the {beta}1 and the {beta}7 integrin genes restricted to the hematopoietic system we show here that {alpha}4{beta}1 and {alpha}4{beta}7 integrins are not essential for differentiation of lymphocytes or myelocytes. However, {beta}1{beta}7 mutant mice displayed a transient increase of CFU-C progenitors in the bone marrow and, after phenylhydrazine-induced anemia, a decreased number of splenic CFUe. Array gene expression analysis of DP and DN thymocytes, and CD19+ and CD4+ splenocytes did not provide any evidence for a compensatory mechanism explaining the mild phenotype. These data show that {alpha}4{beta}1 and {alpha}4{beta}7 are not required for blood cell differentiation, although in their absence alterations in numbers and distribution of progenitor cells were observed.


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