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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1363-1369. Prepublished online as a Blood First Edition Paper on April 18, 2006; DOI 10.1182/blood-2005-12-008755. This Article Full Text (PDF) All Versions of this Article: blood-2005-12-008755v1 108/4/1363    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chiu, B. C.-H. Articles by Weisenburger, D. D Search for Related Content PubMed PubMed Citation Articles by Chiu, B. C.-H. Articles by Weisenburger, D. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 14, 2005 Accepted April 11, 2006 Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma Brian C.-H. Chiu*, Bhavana J Dave, Aaron Blair, Susan M Gapstur, Shelia Hoar Zahm, and Dennis D Weisenburger Department of Preventive Medicine, Northwestern University Medical School, Chicago, IL University of Nebraska Medical Center, Omaha, NE Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD,USA Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE * Corresponding author; email: bchiu{at}northwestern.edu. Pesticides have been specifically associated with the t (14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14;18) status, we obtained 175 tumor blocks from cases in a population- based case-control study conducted in Nebraska between 1983-1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)- positive and 107 t(14;18)-negative cases with those among 1,243 controls. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHL was significantly elevated among farmers who used animal insecticides (OR=2.6; 1.0-6.9), crop insecticides (OR=3.0; 1.1-8.2), herbicides (OR=2.9; 1.1-7.9), and fumigants (OR=5.0; 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t (14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL, but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Agopian, J.-M. Navarro, A.-C. Gac, Y. Lecluse, M. Briand, P. Grenot, P. Gauduchon, P. Ruminy, P. Lebailly, B. Nadel, et al. Agricultural pesticide exposure and the molecular connection to lymphomagenesis J. Exp. Med., July 6, 2009; 206(7): 1473 - 1483. [Abstract] [Full Text] [PDF] L. M. Morton, S. S. Wang, W. Cozen, M. S. Linet, N. Chatterjee, S. Davis, R. K. Severson, J. S. Colt, M. A. Vasef, N. 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Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph) Blood, July 15, 2007; 110(2): 695 - 708. [Abstract] [Full Text] [PDF] L. S. Engel, F. Laden, A. Andersen, P. T. Strickland, A. Blair, L. L. Needham, D. B. Barr, M. S. Wolff, K. Helzlsouer, D. J. Hunter, et al. Polychlorinated Biphenyl Levels in Peripheral Blood and Non-Hodgkin's Lymphoma: A Report from Three Cohorts Cancer Res., June 1, 2007; 67(11): 5545 - 5552. [Abstract] [Full Text] [PDF] B. C.-H. Chiu, B. J. Dave, A. Blair, S. M. Gapstur, J. S. Chmiel, A. J. Fought, S. H. Zahm, and D. D. Weisenburger Cigarette Smoking, Familial Hematopoietic Cancer, Hair Dye Use, and Risk of t(14;18)-defined Subtypes of Non-Hodgkin's Lymphoma Am. J. Epidemiol., March 15, 2007; 165(6): 652 - 659. [Abstract] [Full Text] [PDF] S. Roulland, J.-M. Navarro, P. Grenot, M. Milili, J. Agopian, B. Montpellier, P. Gauduchon, P. 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