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Blood, 1 October 2006, Vol. 108, No. 7, pp. 2190-2197. Prepublished online as a Blood First Edition Paper on June 1, 2006; DOI 10.1182/blood-2005-12-010272. This Article Full Text (PDF) All Versions of this Article: blood-2005-12-010272v1 108/7/2190    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Xing, Z. Articles by Geiger, H. Search for Related Content PubMed PubMed Citation Articles by Xing, Z. Articles by Geiger, H. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 4, 2005 Accepted May 20, 2006 Increased hematopoietic stem cell mobilization in aged mice Zhenlan Xing, Marnie A Ryan, Deidre Daria, Kalpana J Nattamai, Gary Van Zant, Lei Wang, Yi Zheng, and Hartmut Geiger* Cincinnati Children's Hospital Medical Center University of Kentucky Medical Center * Corresponding author; email: hartmut.geiger{at}cchmc.org. Hematopoietic stem and progenitor cells (HSPCs) are located in the bone marrow in close association with a highly organized 3-dimensional structure formed by stroma cells which is referred to as the niche. Mobilization of HSPCs from bone marrow into peripheral blood in response to granulocyte colony-stimulating factor (G-CSF) requires the de-adhesion of HSPCs from the niche. The influence of aging of HSPCs on cell- stroma interactions has not been determined in detail. Using a mouse model of G-CSF induced mobilization, we demonstrate that the ability to mobilize hematopoietic stem cells is approximately 5-fold increased in aged mice. Competitive mobilization experiments confirmed that enhanced mobilization ability was intrinsic to the stem cell. Enhanced mobilization efficiency of primitive hematopoietic cells from aged mice correlated with reduced adhesion of hematopoietic progenitor cells to stroma and with elevated levels of GTP-bound Cdc42. These results might indicate that stroma/ stem cell interactions are dynamic over a lifetime, resulting in physiologically relevant changes in the biology of primitive hematopoietic cells with age. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Jeong, Z.-H. Piao, M. S. Kim, S. H. Lee, S. Yun, H.-n. Sun, S. R. Yoon, J. W. Chung, T.-D. Kim, J. H. Jeon, et al. Thioredoxin-Interacting Protein Regulates Hematopoietic Stem Cell Quiescence and Mobilization under Stress Conditions J. Immunol., August 15, 2009; 183(4): 2495 - 2505. [Abstract] [Full Text] [PDF] A. Kohler, V. Schmithorst, M.-D. Filippi, M. A. Ryan, D. Daria, M. Gunzer, and H. Geiger Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones Blood, July 9, 2009; 114(2): 290 - 298. [Abstract] [Full Text] [PDF] J.-J. Lataillade, O. Pierre-Louis, H. C. Hasselbalch, G. Uzan, C. Jasmin, M.-C. Martyre, M.-C. Le Bousse-Kerdiles, and on behalf of the French INSERM and the European EU Does primary myelofibrosis involve a defective stem cell niche? From concept to evidence Blood, October 15, 2008; 112(8): 3026 - 3035. [Abstract] [Full Text] [PDF] S. Vasu, S. F. Leitman, J. F. Tisdale, M. M. Hsieh, R. W. Childs, A. J. Barrett, D. H. Fowler, M. R. Bishop, E. M. Kang, H. L. Malech, et al. Donor demographic and laboratory predictors of allogeneic peripheral blood stem cell mobilization in an ethnically diverse population Blood, September 1, 2008; 112(5): 2092 - 2100. [Abstract] [Full Text] [PDF] M. Thill, N. V. Strunnikova, M. J. Berna, N. Gordiyenko, K. Schmid, S. W. Cousins, D. J. S. Thompson, and K. G. Csaky Late Outgrowth Endothelial Progenitor Cells in Patients with Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., June 1, 2008; 49(6): 2696 - 2708. [Abstract] [Full Text] [PDF] O. Krejci, M. Wunderlich, H. Geiger, F.-S. Chou, D. Schleimer, M. Jansen, P. R. Andreassen, and J. C. Mulloy p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death Blood, February 15, 2008; 111(4): 2190 - 2199. [Abstract] [Full Text] [PDF] D. Daria, M.-D. Filippi, E. S. Knudsen, R. Faccio, Z. Li, T. Kalfa, and H. Geiger The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress Blood, February 15, 2008; 111(4): 1894 - 1902. [Abstract] [Full Text] [PDF] L. Wang, L. Yang, M. Debidda, D. Witte, and Y. Zheng Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes PNAS, January 23, 2007; 104(4): 1248 - 1253. [Abstract] [Full Text] [PDF]

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