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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1230-1233. Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2005-12-013508. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2005-12-013508v1 108/4/1230    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bonig, H. Articles by Papayannopoulou, T. Search for Related Content PubMed PubMed Citation Articles by Bonig, H. Articles by Papayannopoulou, T. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 8, 2005 Accepted March 30, 2006 The p67 laminin-receptor identifies human erythroid progenitor and precursor cells and is functionally important for their bone marrow lodgment Halvard Bonig*, Kai-Hsin Chang, Betty Nakamoto, and Thalia Papayannopoulou Dept. of Medicine/Hematology, University of Washington, Seattle, WA * Corresponding author; email: hbonig{at}u.washington.edu. The laminins are a group of extracellular matrix proteins with constitutive expression in all tissues, including bone marrow stroma. A functional role for the non- integrin laminin-receptor p67 has been described for cancer metastasis and lymphocyte trafficking. Expression of p67 was also reported for other subsets of mature leukocytes and for malignant hematopoietic or non-hematopoietic cells. We explored p67-expression on normal hematopoietic progenitor cells (HPC) and its putative role in bone marrow retention of transplanted HPC. We found p67 expression on a subset of primary human CD34+ cells co-expressing erythroid markers. Importantly, p67 recognizes early erythroid progenitors, since sorted p67+ cells were significantly enriched for burst-forming units-erythroid (BFU-E) and depleted of colony-forming units-granulocyte/macrophage (CFU-GM). Blockade of p67-binding of donor cells, using anti-functional antibody, reduced bone marrow homing of BFU-E. These studies identify p67 as a novel phenotypic marker for erythroid HPC, of functional importance for lineage-specific homing/retention among adult transplanted HPC. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Qian, E. Georges-Labouesse, A. Nystrom, A. Domogatskaya, K. Tryggvason, S. E. W. Jacobsen, and M. Ekblom Distinct roles of integrins {alpha}6 and {alpha}4 in homing of fetal liver hematopoietic stem and progenitor cells Blood, October 1, 2007; 110(7): 2399 - 2407. [Abstract] [Full Text] [PDF]

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