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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2687-2694.
Prepublished online as a Blood First Edition Paper on July 6, 2006; DOI 10.1182/blood-2005-12-017319.
 Previous Article | Next Article 
Submitted December 20, 2005
Accepted June 7, 2006
A Role for BLyS in the activation of innate immune cells
Sook Kyung Chang, Bonnie K Arendt, Jaime R Darce, Xiaosheng Wu, and Diane F Jelinek*
Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN, USA
* Corresponding author; email: jelinek.diane{at}mayo.edu.
B lymphocyte stimulator (BLyS) is a member of the tumor
necrosis factor (TNF) ligand superfamily. Although BLyS
costimulates adaptive immune cells, the ability of BLyS
to stimulate innate immune cells has not been described.
Here, we show that BLyS strongly induces human monocyte
survival, and activation as measured by proinflammatory
cytokine secretion and up-regulation of costimulatory
molecule expression. In addition, monocytes cultured
with BLyS differentiated into macrophage-like cells.
Regarding BLyS receptor(s) expression, freshly isolated
monocytes bound low levels of exogenous BLyS, expressed
primarily intracellular TACI, and cell surface TACI
levels increased following monocyte activation. Of
interest, bone marrow monocytes from some multiple
myeloma patients expressed significant levels of cell
surface TACI at isolation. Our findings indicate that
BLyS plays a role in activating innate immune cells.
Moreover, this study may explain more clearly why high
BLyS production is often correlated with certain
inflammatory autoimmune diseases and B lymphocyte
malignancies.
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