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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2608-2615. Prepublished online as a Blood First Edition Paper on June 29, 2006; DOI 10.1182/blood-2005-12-019919. This Article Full Text (PDF) Supplemental Figures and Videos All Versions of this Article: blood-2005-12-019919v1 108/8/2608    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fons, P. Articles by Le Bouteiller, P. Search for Related Content PubMed PubMed Citation Articles by Fons, P. Articles by Le Bouteiller, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 22, 2005 Accepted June 6, 2006 Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells Pierre Fons, Sophie Chabot, Judith E Cartwright, Francoise Lenfant, Fatima L'Faqihi, Jerome Giustiniani, Jean-Pascal Herault, Genevieve Gueguen, Francoise Bono, Pierre Savi, Maryse Aguerre-Girr, Sylvie Fournel, Francois Malecaze, Armand Bensussan, Jean Plouet, and Philippe Le Bouteiller* IPBS Unite Mixte de Recherche 5089, Toulouse, France; Sanofi-Aventis Research, Toulouse, France Institut National de la Sante et de la Recherche Medicale Unite 563/Universite Paul Sabatier, France Department of Basic Medical Sciences, St. George's, University of London, UK Institut National de la Sante et de la Recherche Medicale Unite 659, Faculte de Medecine de Creteil Sanofi-Aventis Research, Toulouse, France IPBS Unite Mixte de Recherche 5089, Toulouse, France; INSERM U689, Paris, France * Corresponding author; email: phil.lb{at}toulouse.inserm.fr. HLA-G is a Major Histocompatibility Complex class Ib molecule whose constitutive tissue distribution is mainly restricted to trophoblast cells at the maternal- fetal interface during pregnancy. In this study we demonstrate the ability of the soluble HLA-G1 (sHLA-G1) isoform to inhibit fibroblast growth factor-2 (FGF2)- induced capillary-like tubule formation. Using a rabbit corneal neovascularization model, we further show that sHLA-G1 inhibits FGF2-induced angiogenesis in vivo. We have also demonstrated that sHLA-G1 induces endothelial cell apoptosis through binding to BY55/CD160, a glycosylphosphatidylinositol-anchored receptor expressed by endothelial cells. Furthermore, we show that the specific CL1-R2 anti-CD160 monoclonal antibody mimics sHLA-G1-mediated inhibition of endothelial cell tube formation and induction of apoptosis. Thus, engagement of CD160 in endothelial cells may be essential for the inhibition of angiogenesis. sHLA-G1/CD160-mediated anti- angiogenic property may participate in the vascular remodeling of maternal spiral arteries during pregnancy, and offers an attractive therapeutic target to prevent pathologic neovascularization as we found that CD160 is strongly expressed in the vasculature of a murine tumor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. McCormick, G. S. J. Whitley, P. Le Bouteiller, and J. E. Cartwright Soluble HLA-G regulates motility and invasion of the trophoblast-derived cell line SGHPL-4 Hum. Reprod., June 1, 2009; 24(6): 1339 - 1345. [Abstract] [Full Text] [PDF] G. C. Douglas, C. A. VandeVoort, P. Kumar, T.-C. Chang, and T. G. Golos Trophoblast Stem Cells: Models for Investigating Trophectoderm Differentiation and Placental Development Endocr. Rev., May 1, 2009; 30(3): 228 - 240. [Abstract] [Full Text] [PDF] P. Moreau, L. Contu, F. Alba, S. Lai, R. Simoes, S. Orru, C. Carcassi, M. Roger, M. Rabreau, and E. D. Carosella HLA-G Gene Polymorphism in Human Placentas: Possible Association of G*0106 Allele with Preeclampsia and Miscarriage Biol Reprod, September 1, 2008; 79(3): 459 - 467. [Abstract] [Full Text] [PDF] E. D. Carosella, B. Favier, N. Rouas-Freiss, P. Moreau, and J. LeMaoult Beyond the increasing complexity of the immunomodulatory HLA-G molecule Blood, May 15, 2008; 111(10): 4862 - 4870. [Abstract] [Full Text] [PDF] C. Y. Tan, J. F.V. Ho, Y. S. Chong, A. Loganath, Y. H. Chan, J. Ravichandran, C. G. Lee, and S. S. Chong Paternal contribution of HLA-G*0106 significantly increases risk for pre-eclampsia in multigravid pregnancies Mol. Hum. Reprod., May 1, 2008; 14(5): 317 - 324. [Abstract] [Full Text] [PDF] J. Szekeres-Bartho and J. Balasch Progestagen therapy for recurrent miscarriage Hum. Reprod. Update, January 1, 2008; 14(1): 27 - 35. [Abstract] [Full Text] [PDF] G. I. Bondarenko, D. W. Burleigh, M. Durning, E. E. Breburda, R. L. Grendell, and T. G. Golos Passive Immunization against the MHC Class I Molecule Mamu-AG Disrupts Rhesus Placental Development and Endometrial Responses J. Immunol., December 15, 2007; 179(12): 8042 - 8050. [Abstract] [Full Text] [PDF] S. Coupel, A. Moreau, M. Hamidou, V. Horejsi, J.-P. Soulillou, and B. Charreau Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation Blood, April 1, 2007; 109(7): 2806 - 2814. [Abstract] [Full Text] [PDF] J.-J. Helwig and P. Le Bouteiller Physiological Smooth Muscle Cell Apoptosis Contributes to the Uterine Vascular Remodeling in Human Early Pregnancy Circ. Res., March 30, 2007; 100(6): 754 - 756. [Full Text] [PDF]

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