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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3068-3071. Prepublished online as a Blood First Edition Paper on July 18, 2006; DOI 10.1182/blood-2006-01-012369. This Article Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2006-01-012369v1 108/9/3068    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Poliseno, L. Articles by Rainaldi, G. Search for Related Content PubMed PubMed Citation Articles by Poliseno, L. Articles by Rainaldi, G. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 11, 2006 Accepted April 18, 2006 MicroRNAs modulate the angiogenic properties of HUVEC Laura Poliseno, Andrea Tuccoli, Laura Mariani, Monica Evangelista, Lorenzo Citti, Keith Woods, Alberto Mercatanti, Scott Hammond, and Giuseppe Rainaldi* Laboratory of Gene and Molecular Therapy, Institute of Clinical Physiology, CNR Department of Cell and Developmental Biology, University of North Carolina * Corresponding author; email: g.rainaldi{at}ifc.cnr.it. microRNAs (miRNAs) have recently come into focus as key post-transcriptional modulators of gene expression. In this work, we addressed the question whether in vitro angiogenesis is a miRNA-regulated process. We performed large-scale analysis of miRNA expression in human umbilical vein endothelial cells (HUVEC) and found that 15 among highly expressed miRNAs have the receptors of angiogenic factors as putative targets. In particular, we demonstrated that miR-221 and miR-222 affect c-Kit expression and, as a consequence, the angiogenic properties of its ligand Stem Cell Factor. The miR-221/2 and c-Kit interaction is likely to be part of a complex circuit that controls the ability of endothelial cells to form new capillaries. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: MicroRNAs control angiogenesis Cesare Peschle Blood 2006 108: 2887-2888. [Full Text] [PDF] This article has been cited by other articles: M. V. Iorio and C. M. Croce MicroRNAs in Cancer: Small Molecules With a Huge Impact J. Clin. Oncol., December 1, 2009; 27(34): 5848 - 5856. [Abstract] [Full Text] [PDF] E. M. C. Ohlsson Teague, C. G. Print, and M. L. 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