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Blood, 1 August 2006, Vol. 108, No. 3, pp. 804-811. Prepublished online as a Blood First Edition Paper on April 6, 2006; DOI 10.1182/blood-2006-02-002774. This Article Full Text (PDF) All Versions of this Article: blood-2006-02-002774v1 108/3/804    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beyer, M. Articles by Schultze, J. L Search for Related Content PubMed PubMed Citation Articles by Beyer, M. Articles by Schultze, J. L Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 14, 2006 Accepted March 16, 2006 Regulatory T cells in cancer Marc Beyer and Joachim L Schultze* Molecular Tumor Biology and Tumor Immunology, Clinic I for Internal Medicine, University of Cologne * Corresponding author; email: joachim.schultze{at}uk-koeln.de. There is increasing evidence for the existence of elevated numbers of regulatory T cells in solid tumors and hematological malignancies. While the biology of CD4+CD25+FOXP3+ regulatory T cells (Treg) in murine models seems to be rather straight-forward, studies in human diseases are more difficult to interpret due to expression of CD25 on activated effector T cells as well as Treg cells. More important, early studies in human tumors were mainly focused on CD4+CD25+ Treg cells lacking interrogation of more specific markers such as FOXP3 expression. While the increase of Treg cells seems to be a characteristic feature in most tumors, little is known about the molecular and cellular mechanisms responsible for the increase and maintenance of elevated levels of Treg cells in cancer. We will discuss earlier data in context of recent findings in Treg cell biology with a particular emphasis on CD4+CD25highFOXP3+ Treg cells in human malignancies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Kimpfler, A. Sevko, S. Ring, C. Falk, W. Osen, K. Frank, M. Kato, K. Mahnke, D. Schadendorf, and V. Umansky Skin Melanoma Development in ret Transgenic Mice Despite the Depletion of CD25+Foxp3+ Regulatory T Cells in Lymphoid Organs J. Immunol., November 15, 2009; 183(10): 6330 - 6337. [Abstract] [Full Text] [PDF] S. G. Holtan, D. J. Creedon, P. Haluska, and S. N. 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Vickers Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma Blood, June 1, 2008; 111(11): 5359 - 5370. [Abstract] [Full Text] [PDF] A. Wakkach, S. Augier, J.-P. Breittmayer, C. Blin-Wakkach, and G. F. Carle Characterization of IL-10-Secreting T Cells Derived from Regulatory CD4+CD25+ Cells by the TIRC7 Surface Marker J. Immunol., May 1, 2008; 180(9): 6054 - 6063. [Abstract] [Full Text] [PDF] L. M. Ebert, B. S. Tan, J. Browning, S. Svobodova, S. E. Russell, N. Kirkpatrick, C. Gedye, D. Moss, S. P. Ng, D. MacGregor, et al. The Regulatory T Cell-Associated Transcription Factor FoxP3 Is Expressed by Tumor Cells Cancer Res., April 15, 2008; 68(8): 3001 - 3009. [Abstract] [Full Text] [PDF] A. P. Castano, P. Mroz, M. X. Wu, and M. R. Hamblin Photodynamic therapy plus low-dose cyclophosphamide generates antitumor immunity in a mouse model PNAS, April 8, 2008; 105(14): 5495 - 5500. [Abstract] [Full Text] [PDF] A. Alisa, S. Boswell, A. A. Pathan, L. Ayaru, R. Williams, and S. Behboudi Human CD4+ T Cells Recognize an Epitope within {alpha}-Fetoprotein Sequence and Develop into TGF-{beta}-Producing CD4+ T Cells J. Immunol., April 1, 2008; 180(7): 5109 - 5117. [Abstract] [Full Text] [PDF] D. Escors, L. Lopes, R. Lin, J. Hiscott, S. Akira, R. J. Davis, and M. K. Collins Targeting dendritic cell signaling to regulate the response to immunization Blood, March 15, 2008; 111(6): 3050 - 3061. [Abstract] [Full Text] [PDF] J. Yokokawa, V. Cereda, C. Remondo, J. L. Gulley, P. M. Arlen, J. Schlom, and K. Y. Tsang Enhanced Functionality of CD4+CD25highFoxP3+ Regulatory T Cells in the Peripheral Blood of Patients with Prostate Cancer Clin. Cancer Res., February 15, 2008; 14(4): 1032 - 1040. [Abstract] [Full Text] [PDF] A. Tzankov, C. Meier, P. Hirschmann, P. Went, S. A. Pileri, and S. Dirnhofer Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma Haematologica, February 1, 2008; 93(2): 193 - 200. [Abstract] [Full Text] [PDF] J. Ribot, G. Enault, S. Pilipenko, A. Huchenq, M. Calise, D. Hudrisier, P. Romagnoli, and J. P. M. van Meerwijk Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection J. Immunol., November 15, 2007; 179(10): 6741 - 6748. [Abstract] [Full Text] [PDF] K. Leon, K. Garcia, J. Carneiro, and A. Lage How Regulatory CD25+CD4+ T Cells Impinge on Tumor Immunobiology: The Differential Response of Tumors to Therapies J. Immunol., November 1, 2007; 179(9): 5659 - 5668. [Abstract] [Full Text] [PDF] B. A. Teicher Transforming Growth Factor-{beta} and the Immune Response to Malignant Disease Clin. Cancer Res., November 1, 2007; 13(21): 6247 - 6251. [Abstract] [Full Text] [PDF] K. Yoshimura, L. S. Laird, C. Y. Chia, K. F. Meckel, J. E. Slansky, J. M. Thompson, A. Jain, D. M. Pardoll, and R. D. Schulick Live Attenuated Listeria Monocytogenes Effectively Treats Hepatic Colorectal Cancer Metastases and Is Strongly Enhanced by Depletion of Regulatory T Cells Cancer Res., October 15, 2007; 67(20): 10058 - 10066. [Abstract] [Full Text] [PDF] S. Hu, J. Dai, H. Wei, K. Fan, H. Wang, D. Zhang, W. Qian, B. Li, H. Wang, T. Zhu, et al. Functional and Stable Expression of Recombinant Human FOXP3 in Bacterial Cells and Development of Antigen-specific Monoclonal Antibodies J. Biochem., October 1, 2007; 142(4): 471 - 480. [Abstract] [Full Text] [PDF] S. G. Kang, H. W. Lim, O. M. Andrisani, H. E. Broxmeyer, and C. H. Kim Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells J. Immunol., September 15, 2007; 179(6): 3724 - 3733. [Abstract] [Full Text] [PDF] A. Annoni, M. Battaglia, A. Follenzi, A. Lombardo, L. Sergi-Sergi, L. Naldini, and M.-G. Roncarolo The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells Blood, September 15, 2007; 110(6): 1788 - 1796. [Abstract] [Full Text] [PDF] E. E. Solomou, K. Rezvani, S. Mielke, D. Malide, K. Keyvanfar, V. Visconte, S. Kajigaya, A. J. Barrett, and N. S. Young Deficient CD4+ CD25+ FOXP3+ T regulatory cells in acquired aplastic anemia Blood, September 1, 2007; 110(5): 1603 - 1606. [Abstract] [Full Text] [PDF] M. Del Vecchio, E. Bajetta, S. Canova, M. T. Lotze, A. Wesa, G. Parmiani, and A. Anichini Interleukin-12: Biological Properties and Clinical Application Clin. Cancer Res., August 15, 2007; 13(16): 4677 - 4685. [Abstract] [Full Text] [PDF] J. Nitcheu-Tefit, M.-S. Dai, R. J. Critchley-Thorne, F. Ramirez-Jimenez, M. Xu, S. Conchon, N. Ferry, H. J. Stauss, and G. Vassaux Listeriolysin O Expressed in a Bacterial Vaccine Suppresses CD4+CD25high Regulatory T Cell Function In Vivo J. Immunol., August 1, 2007; 179(3): 1532 - 1541. [Abstract] [Full Text] [PDF] L. Strauss, C. Bergmann, M. Szczepanski, W. Gooding, J. T. Johnson, and T. L. Whiteside A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-{beta}1 Mediates Suppression in the Tumor Microenvironment Clin. Cancer Res., August 1, 2007; 13(15): 4345 - 4354. [Abstract] [Full Text] [PDF] V. Touitou, C. Daussy, B. Bodaghi, S. Camelo, Y. de Kozak, P. Lehoang, M.-C. Naud, A. Varin, B. Thillaye-Goldenberg, H. Merle-Beral, et al. Impaired Th1/Tc1 Cytokine Production of Tumor-Infiltrating Lymphocytes in a Model of Primary Intraocular B-Cell Lymphoma Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3223 - 3229. [Abstract] [Full Text] [PDF] M. Beyer and J. L. Schultze CD4+CD25highFOXP3+ Regulatory T Cells in Peripheral Blood Are Primarily of Effector Memory Phenotype J. Clin. Oncol., June 20, 2007; 25(18): 2628 - 2630. [Full Text] [PDF] N. Suciu-Foca, N. Feirt, Q.-Y. Zhang, G. Vlad, Z. Liu, H. Lin, C.-C. Chang, E. K. Ho, A. I. Colovai, H. Kaufman, et al. Soluble Ig-Like Transcript 3 Inhibits Tumor Allograft Rejection in Humanized SCID Mice and T Cell Responses in Cancer Patients J. Immunol., June 1, 2007; 178(11): 7432 - 7441. [Abstract] [Full Text] [PDF] B. Huang, J. Zhao, S. Shen, H. Li, K.-L. He, G.-X. Shen, L. Mayer, J. Unkeless, D. Li, Y. Yuan, et al. Listeria monocytogenes Promotes Tumor Growth via Tumor Cell Toll-Like Receptor 2 Signaling Cancer Res., May 1, 2007; 67(9): 4346 - 4352. [Abstract] [Full Text] [PDF] S. A. Perez, M. V. Karamouzis, D. V. Skarlos, A. Ardavanis, N. N. Sotiriadou, E. G. Iliopoulou, M. L. Salagianni, G. Orphanos, C. N. Baxevanis, G. Rigatos, et al. CD4+CD25+ Regulatory T-Cell Frequency in HER-2/neu (HER)-Positive and HER-Negative Advanced-Stage Breast Cancer Patients Clin. Cancer Res., May 1, 2007; 13(9): 2714 - 2721. [Abstract] [Full Text] [PDF]

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