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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1388-1394. Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2006-02-003681. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2006-02-003681v1 108/4/1388    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ohgami, R. S Articles by Fleming, M. D Search for Related Content PubMed PubMed Citation Articles by Ohgami, R. S Articles by Fleming, M. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 16, 2006 Accepted March 23, 2006 The Steap proteins are metalloreductases Robert S Ohgami, Dean R Campagna, Alice McDonald, and Mark D Fleming* Department of Pathology, Children's Hospital and Harvard Medical School, Boston, MA Millennium Pharmaceuticals, Cambridge, MA * Corresponding author; email: mark.fleming{at}childrens.harvard.edu. Iron and copper are essential for all organisms, assuming critical roles as cofactors in many enzymes. In eukaryotes, the transmembrane transport of these elements is a highly regulated process facilitated by the single electron reduction of each metal. Previously, we identified a mammalian ferrireductase, Steap3, critical for erythroid iron homeostasis. Now, through homology, expression, and functional studies, we characterize all four members of this protein family and demonstrate that three of them, Steap2, Steap3, and Steap4 are not only ferrireductases, but also cupric reductases that stimulate cellular uptake of both iron and copper in vitro. Finally, the pattern of tissue expression and subcellular localization of these proteins suggest they are physiologically relevant cupri- and ferri-reductases in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. H. Kaplan and S. Lutsenko Copper Transport in Mammalian Cells: Special Care for a Metal with Special Needs J. Biol. Chem., September 18, 2009; 284(38): 25461 - 25465. [Abstract] [Full Text] [PDF] A. Iolascon, L. De Falco, and C. Beaumont Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis Haematologica, March 1, 2009; 94(3): 395 - 408. 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