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Blood, 15 October 2006, Vol. 108, No. 8, pp. 2755-2763. Prepublished online as a Blood First Edition Paper on June 27, 2006; DOI 10.1182/blood-2006-02-005488. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-02-005488v1 108/8/2755    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chng, W. J Articles by Bergsagel, L. Search for Related Content PubMed PubMed Citation Articles by Chng, W. J Articles by Bergsagel, L. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 22, 2006 Accepted June 5, 2006 Gene expression profiling of Waldenstrom's macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma Wee J Chng, Roelandt Schop, Tammy Price-Troska, Irene Ghobrial, Neil Kay, Diane F Jelinek, Morie A Gertz, Angela Dispenzieri, Martha Lacy, Robert A Kyle, Philip R Greipp, Renee C Tschumper, Rafael Fonseca, and Leif Bergsagel* Department of Hematology-Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA Division of Hematology, Mayo Clinic College of Medicine, MN, USA Dana Faber Cancer Institute, Boston, MA, USA Division of Internal Medicine, Mayo Clinic College of Medicine,Mayo Graduate School Rochester,MN,USA Department of Immunology and Division of Hematology, Mayo Clinic College of Medicine, MN, USA * Corresponding author; email: bergsagel.leif{at}mayo.edu. Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy characterized by the ability of the B-cell clone to differentiate into plasma cells. Although the clinical syndrome and the pathological characteristics are well defined, little is known about its biology and controversy still exists regarding its cell of origin. In this gene expression study, we compared the transcription profiles of WM with those of other malignant B cells including (chronic lymphocytic leukemia (CLL) and multiple myeloma (MM)) as well as normal cells (peripheral blood B-cells and bone marrow plasma cells). We found that WM has a homogenous gene expression regardless of 6q deletion status and clusters with CLL and normal B-cells on unsupervised clustering with very similar expression profiles. Only a small gene set has expression profiles unique to WM compared to CLL and MM. The most significantly up-regulated gene is IL6 and the most significantly associated pathway for this set of genes is MAPK signaling. Thus, IL6 and its downstream signaling may be of biologic importance in WM. Further elucidation of the role of IL-6 in WM is warranted as this may offer a potential therapeutic avenue. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Gene expression relates WM to CLL Adrian Wiestner Blood 2006 108: 2499-2500. [Full Text] [PDF] This article has been cited by other articles: L. R. Goldin, M. Bjorkholm, S. Y. Kristinsson, I. Turesson, and O. Landgren Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia Haematologica, May 1, 2009; 94(5): 647 - 653. [Abstract] [Full Text] [PDF] A. M. Roccaro, A. Sacco, C. Chen, J. Runnels, X. Leleu, F. Azab, A. K. Azab, X. Jia, H. T. Ngo, M. R. 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