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Blood, 1 September 2006, Vol. 108, No. 5, pp. 1767-1769. Prepublished online as a Blood First Edition Paper on April 27, 2006; DOI 10.1182/blood-2006-02-005645. This Article Full Text (PDF) All Versions of this Article: blood-2006-02-005645v1 108/5/1767    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Burkholder, T. H Articles by Hickstein, D. D Search for Related Content PubMed PubMed Citation Articles by Burkholder, T. H Articles by Hickstein, D. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 23, 2006 Accepted April 15, 2006 Reproductive capability in dogs with canine leukocyte adhesion deficiency treated with non-myeloablative conditioning prior to allogeneic hematopoietic stem cell transplantation Tanya H Burkholder*, Lyn Colenda, Laura M Tuschong, Matthew F Starost, Thomas R Bauer, Jr., and Dennis D Hickstein National Institutes of Health, Bethesda, MD, USA * Corresponding author; email: burkholt{at}mail.nih.gov. Non-myeloablative conditioning regimens are increasingly replacing myeolablative conditioning prior to allogeneic hematopoietic stem cell transplantation (SCT). The recent advent of these conditioning regimens has limited the assessment of the long-term effects of this treatment, including analysis of reproductive function. To address the question of reproductive function after non-myeloablative transplant, we analyzed a cohort of young dogs with the genetic disease canine leukocyte adhesion deficiency who were treated with a non-myeloablative dose of 200 cGy total body irradiation followed by matched littermate SCT. Five males and five females entered puberty; all 5 males and 4 females subsequently sired or delivered litters following transplant. We demonstrate that fertility is intact and dogs have uncomplicated parturitions following non-myeloablative conditioning for SCT. These results are encouraging for children and adults of child bearing age who receive similar conditioning regimens prior to allogeneic transplant. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W. Qasim, M. Cavazzana-Calvo, E. G. Davies, J. Davis, M. Duval, G. Eames, N. Farinha, A. Filopovich, A. Fischer, W. Friedrich, et al. Allogeneic Hematopoietic Stem-Cell Transplantation for Leukocyte Adhesion Deficiency Pediatrics, March 1, 2009; 123(3): 836 - 840. [Abstract] [Full Text] [PDF]

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