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Blood, 15 November 2006, Vol. 108, No. 10, pp. 3560-3563.
Prepublished online as a Blood First Edition Paper on July 27, 2006; DOI 10.1182/blood-2006-03-010835.
Previous Article | Next Article 
Submitted March 21, 2006
Accepted May 22, 2006
Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Elise Chapiro, Lisa Russell, Isabelle Radford-Weiss, Christian Bastard, Michel Lessard, Stephanie Struski, Helene Cave, Sandra Fert-Ferrer, Carole Barin, Odile Maarek, Veronique Della-Valle, Jonathan C Strefford, Roland Berger, Christine J Harrison, Olivier A Bernard, and Florence Nguyen-Khac*
INSERM; APHP Service d'Hematologie Biologique, Hopital Pitie-Salpetriere
Leukaemia Research Cytogenetics Group, University of Southampton, Southampton, UK
INSERM; APHP Laboratoire de Cytogenetique, Hopital Necker-Enfants Malades
Laboratoire de Genetique Oncologique, Rouen
Laboratoire d'Hematologie, Hopital Hautepierre, Strasbourg
APHP Laboratoire de Biochimie Genetique, Hopital Robert Debre
Laboratoire de Genetique, Centre Hospitalier de CHAMBERY
Laboratoire de Genetique, Tours, France
APHP Laboratoire d'Hematologie, Hopital Saint-Louis, Paris, France
INSERM, E0210, Paris France; Univ Rene Descarte, Paris, France
* Corresponding author; email: florence.nguyen{at}psl.aphp.fr.
Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation, indirect and post-translational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy chain locus in precursor B cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Over-expression of apparently normal CEBPA RNA or protein was observed in 6 cases. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.

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