Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 January 2007, Vol. 109, No. 1, pp. 22-30.
Prepublished online as a Blood First Edition Paper on September 12, 2006; DOI 10.1182/blood-2006-04-015206.

This Article
Right arrow Full Text (PDF)
Right arrow Retraction (v111,p2537)
Right arrow All Versions of this Article:
blood-2006-04-015206v1
109/1/22    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsuyama, W.
Right arrow Articles by Arimura, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsuyama, W.
Right arrow Articles by Arimura, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted April 7, 2006
Accepted August 16, 2006

Discoidin domain receptor 1 contributes to eosinophil survival in an NF-{kappa}B dependent manner in Churg-Strauss syndrome

Wataru Matsuyama*, Hideo Mitsuyama, Mikiko Ono, Yuko Shirahama, Ikkou Higashimoto, Mituhiro Osame, and Kimiyoshi Arimura

Division of Respiratory Medicine, Kagoshima, University Hospital, Kagoshima, Japan

* Corresponding author; email: vega{at}xa2.so-net.ne.jp.

Churg-Strauss syndrome (CSS) is a systemic disease that shows marked eosinophilia along with eosinophil infiltration in the tissue. Prolonged eosinophil survival plays an important role in the pathogenesis of CSS; however, its detailed molecular mechanism remains unclear. Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase, and its ligand is collagen. DDR1 was expressed in human leukocytes and fibroblasts, and it plays an important role in leukocyte cytokine production and fibroblast survival in an NF-{kappa}B dependent manner. In this study, we examined in vitro and in vivo eosinophil DDR1 expression and its function in CSS patients. The expression level of DDR1 was significantly higher in the eosinophils of CSS patients, and the predominant isoform was DDR1b. Immunohistochemical findings revealed that the tissue-infiltrating eosinophils expressed endogenous DDR1. In CSS patients, DDR1 activation inhibited Fas agonistic antibody-induced apoptosis and up-regulated Fas agonistic antibody-induced cytokine production of eosinophils in an NF-{kappa}B dependent manner. Suppression of DDR1 expression in the eosinophils by using RNA interference and addition of the DDR1 blocking protein abolished these effects. We propose that DDR1 contributes to the eosinophil survival in the tissue microenvironment of CSS and that it might be involved in the development of CSS.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
J. A. Gomez-Puerta and X. Bosch
Anti-Neutrophil Cytoplasmic Antibody Pathogenesis in Small-Vessel Vasculitis: An Update
Am. J. Pathol., November 1, 2009; 175(5): 1790 - 1798.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020