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Blood, 1 May 2007, Vol. 109, No. 9, pp. 3890-3894. Prepublished online as a Blood First Edition Paper on January 11, 2007; DOI 10.1182/blood-2006-04-015719. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2006-04-015719v1 109/9/3890    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Weck, M. M. Articles by Brossart, P. Search for Related Content PubMed PubMed Citation Articles by Weck, M. M. Articles by Brossart, P. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 7, 2006 Accepted August 14, 2006 TLR ligands differentially affect uptake and presentation of cellular antigens Markus Michael Weck, Frank Grunebach, Daniela Werth, Christian Sinzger, Anita Bringmann, and Peter Brossart* Department of Oncology, Hematology, Immunology, Rheumatology and Pulmology, University of Tubingen, Tubingen, Germany Institute of Medical Virology, University of Tubingen, Tubingen, Germany * Corresponding author; email: peter.brossart{at}med.uni-tuebingen.de. Dendritic cells (DCs) have the unique ability to efficiently present T-cell epitopes from exogenous antigens on MHC class I molecules, a process called cross-presentation. In our study we demonstrate that stimulation of monocyte-derived DCs with Toll-like receptor (TLR) ligands differentially affects the uptake and cross-presentation of cellular antigens. Activation of DCs with TLR3 or TLR4 but not with TLR2 or TLR7/8 ligands inhibited phagocytosis of apoptotic tumor cells and resulted in a reduced cross-presentation of pp65-derived T-cell epitopes on MHC class I molecules upon engulfment of cytomegalovirus (CMV)-infected fibroblasts. These results have an important impact on the understanding of the interactions between the immune system and pathogens and the development of vaccination strategies to treat malignant diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Jiang, Y. Ke, D. Sun, Y. Wang, H. J. Kaplan, and H. Shao Regulatory Role of TLR Ligands on the Activation of Autoreactive T Cells by Retinal Astrocytes Invest. Ophthalmol. Vis. Sci., October 1, 2009; 50(10): 4769 - 4776. [Abstract] [Full Text] [PDF] I. Tirapu, B. Giquel, L. Alexopoulou, S. Uematsu, R. Flavell, S. Akira, and S. S. Diebold PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation Int. Immunol., July 1, 2009; 21(7): 871 - 879. [Abstract] [Full Text] [PDF] F. N. Toka, C. K. Nfon, H. Dawson, and W. T. Golde Accessory-Cell-Mediated Activation of Porcine NK Cells by Toll-Like Receptor 7 (TLR7) and TLR8 Agonists Clin. Vaccine Immunol., June 1, 2009; 16(6): 866 - 878. [Abstract] [Full Text] [PDF] M. Mandron, H. Martin, B. Bonjean, J. Lule, E. Tartour, and C. Davrinche Dendritic cell-induced apoptosis of human cytomegalovirus-infected fibroblasts promotes cross-presentation of pp65 to CD8+ T cells J. Gen. Virol., January 1, 2008; 89(1): 78 - 86. [Abstract] [Full Text] [PDF]

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