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Blood, 1 October 2006, Vol. 108, No. 7, pp. 2420-2427. Prepublished online as a Blood First Edition Paper on June 13, 2006; DOI 10.1182/blood-2006-04-015933. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2006-04-015933v1 108/7/2420    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Swartz, J. M Articles by Rosenberg, H. F Search for Related Content PubMed PubMed Citation Articles by Swartz, J. M Articles by Rosenberg, H. F Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 1, 2005 Accepted May 29, 2006 Schistosoma mansoni infection in eosinophil lineage-ablated mice Jonathan M Swartz, Kimberly D Dyer, Allen W Cheever, Thirumalai Ramalingam, Lesley Pesnicak, Joseph B Domachowske, James J Lee, Nancy A Lee, Paul S Foster, Thomas A Wynn, and Helene F Rosenberg* National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA SUNY Upstate Medical University, Syracuse, NY, USA Mayo Clinic Arizona, Scottsdale, Arizona, USA Hunter Medical Research Institute, University of Newcastle, NSW, Australia * Corresponding author; email: hrosenberg{at}niaid.nih.gov. We explore the controversial issue of the role of eosinophils in host defense against helminthic parasites using the established Schistosoma mansoni infection model in two novel mouse models of eosinophil lineage ablation (dblGATA and TgPHIL). No eosinophils were detected in bone marrow of infected dblGATA or TgPHIL mice, despite the fact that serum IL-5 levels in these infected mice exceeded those in infected wild type by ~ 4-fold. Liver granulomata from infected dblGATA and TgPHIL mice were likewise depleted of eosinophils compared to those from their respective wild types. No eosinophil-dependent differences in granuloma number, size, or fibrosis were detected at weeks 8 or 12 of infection, and differential accumulation of mast cells was observed among the dblGATA mice only at week 12. Likewise, serum levels of liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased in all mice in response to S. mansoni infection, with no eosinophil-dependent differences in hepatocellular damage observed. Finally, eosinophil ablation had no effect on worm burden or on egg deposition. Overall, our data indicate that eosinophils have no impact on traditional measures of disease in the S. mansoni infection model in mice. However, eosinophils may have unexplored immunomodulatory contributions to this disease process. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. M. Percopo, Z. Qiu, S. Phipps, P. S. Foster, J. B. Domachowske, and H. F. Rosenberg Pulmonary Eosinophils and Their Role in Immunopathologic Responses to Formalin-Inactivated Pneumonia Virus of Mice J. Immunol., July 1, 2009; 183(1): 604 - 612. [Abstract] [Full Text] [PDF] E. S. Magalhaes, C. N. Paiva, H. S. P. Souza, A. S. Pyrrho, D. Mourao-Sa, R. T. Figueiredo, A. Vieira-de-Abreu, H. S. Dutra, M. S. Silveira, M. I. C. Gaspar-Elsas, et al. Macrophage migration inhibitory factor is critical to interleukin-5-driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection FASEB J, April 1, 2009; 23(4): 1262 - 1271. [Abstract] [Full Text] [PDF] V. Fabre, D. P. Beiting, S. K. Bliss, N. G. Gebreselassie, L. F. Gagliardo, N. A. Lee, J. J. Lee, and J. A. Appleton Eosinophil Deficiency Compromises Parasite Survival in Chronic Nematode Infection J. Immunol., February 1, 2009; 182(3): 1577 - 1583. [Abstract] [Full Text] [PDF] K. D. Dyer, J. M. Moser, M. Czapiga, S. J. Siegel, C. M. Percopo, and H. F. Rosenberg Functionally Competent Eosinophils Differentiated Ex Vivo in High Purity from Normal Mouse Bone Marrow J. Immunol., September 15, 2008; 181(6): 4004 - 4009. [Abstract] [Full Text] [PDF] F. Verzegnassi, R. M. Boucher, L. Gilbert-McClain, B. Chowdhury, D. R. Boulware, W. M. Stauffer III, P. F. Walker, M. E. Rothenberg, P. F. Weller, and A. Klion Hypereosinophilic syndrome and mepolizumab. N. Engl. J. Med., June 26, 2008; 358(26): 2838 - 2838. [Full Text] [PDF] D. Yang, Q. Chen, S. B. Su, P. Zhang, K. Kurosaka, R. R. Caspi, S. M. Michalek, H. F. Rosenberg, N. Zhang, and J. J. Oppenheim Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses J. Exp. Med., January 21, 2008; 205(1): 79 - 90. [Abstract] [Full Text] [PDF] D. P. McManus and A. Loukas Current Status of Vaccines for Schistosomiasis Clin. Microbiol. Rev., January 1, 2008; 21(1): 225 - 242. [Abstract] [Full Text] [PDF] K. D. Dyer, M. Czapiga, B. Foster, P. S. Foster, E. M. Kang, C. M. Lappas, J. M. Moser, N. Naumann, C. M. Percopo, S. J. Siegel, et al. Eosinophils from Lineage-Ablated {Delta}dblGATA Bone Marrow Progenitors: The dblGATA Enhancer in the Promoter of GATA-1 Is Not Essential for Differentiation Ex Vivo J. Immunol., August 1, 2007; 179(3): 1693 - 1699. [Abstract] [Full Text] [PDF]

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