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Blood, 1 March 2007, Vol. 109, No. 5, pp. 2058-2065. Prepublished online as a Blood First Edition Paper on November 16, 2006; DOI 10.1182/blood-2006-04-016451. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2006-04-016451v1 109/5/2058    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Garin, M. I Articles by Lechler, R. I Search for Related Content PubMed PubMed Citation Articles by Garin, M. I Articles by Lechler, R. I Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 17, 2006 Accepted September 26, 2006 Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells Marina I Garin, Chung-Ching Chu, Dela Golshayan, Eva Cernuda-Morollon, Robin Wait, and Robert I Lechler* Laboratorio de Hematopoyesis y Terapia Genica, CIEMAT, Madrid, Spain Department of Nephrology and Transplantation, King's College and St. Thomas' Hospitals, London, United Kingdom Division of Nephrology and Transplant Centre, CHUV, Lausanne, Switzerland Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London, United Kingdom Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom * Corresponding author; email: robert.lechler{at}kcl.ac.uk. The naturally occurring population of dedicated regulatory T cells that co-express CD4 and CD25 is known to play a key role in the maintenance of peripheral T cell tolerance; however, their mechanism of action has remained obscure. Here we report that a member of the family of -galactoside-binding proteins, galectin-1, is over-expressed in regulatory T cells, and that expression is increased after activation. Most importantly, blockade of galectin-1 binding significantly reduced the inhibitory effects of human and mouse CD4+CD25+ T cells. Reduced regulatory activity was observed in CD4+CD25+ T cells obtained from galectin-1 homozygous null mutant mice. These results suggest that galectin-1 is a key effector of the regulation mediated by these cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Lahl, C. T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. 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