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Blood, 1 November 2006, Vol. 108, No. 9, pp. 3094-3102.
Prepublished online as a Blood First Edition Paper on July 11, 2006; DOI 10.1182/blood-2006-04-016659.
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Submitted December 19, 2005
Accepted June 15, 2006
Presence of neutrophil bearing antigen in lymphoid organs
of immune mice
Belkys A Maletto, Andrea S Ropolo, Diego O Alignani, Miriam V Liscovsky, Romina P Ranocchia, Victor G Moron, and Maria C Pistoresi-Palencia*
Departamento de Bioquimica Clinica, CIBICI (CONICET), Facultad de Ciencias Quimicas, UNC
* Corresponding author; email: cpistore{at}mail.fcq.unc.edu.ar.
Neutrophils play a crucial early role during the innate
response, but little is known about their possible
contribution when an adaptative immune response is
installed. A robust neutrophilia and a Th1 immune
response are present after immunization with Complete
Freund's Adjuvant (CFA). We show that when FITC-labeled
OVA was injected into the footpad of OVA/CFA immunized
mice, the main OVA-FITC+ cells recruited in draining
popliteal lymph nodes (LN) were neutrophils, with most
of them arriving at the LN by means of lymphatic
vessels. The development of this OVA-FITC+ neutrophil
influx requires an immune response against OVA. The OVA-
FITC+ neutrophils present in LN displayed mainly
intracellular TNF- and their depletion resulted in an
increase in the specific IL-5 levels. These data provide
new evidence about the role played by neutrophils in
vivo in adaptative immunity.
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