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Blood, 15 May 2007, Vol. 109, No. 10, pp. 4548-4556. Prepublished online as a Blood First Edition Paper on February 8, 2007; DOI 10.1182/blood-2006-04-017442. This Article Full Text (PDF) All Versions of this Article: blood-2006-04-017442v1 109/10/4548    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hossain, M. S Articles by Waller, E. K Search for Related Content PubMed PubMed Citation Articles by Hossain, M. S Articles by Waller, E. K Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 20, 2006 Accepted January 16, 2007 Chronic GvHD decreases anti-viral immune responses in allogeneic BMT Mohammad S Hossain, John D Roback, Brian P Pollack, David L. Jaye, Amelia Langston, and Edmund K Waller* Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory University, Atlanta, GA, United States Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States Departments of Dermatology and Pathology, Emory University, Atlanta, GA, United States * Corresponding author; email: ewaller{at}emory.edu. Chronic graft-versus-host-disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific anti-viral immunity and compared BMT recipients with cGvHD to control groups of allogeneic BMT recipients without GvHD. Mice with and without cGvHD received a non-lethal dose of murine cytomegalovirus (MCMV) +100 days post transplant. Recipients with cGvHD had more weight loss and higher viral loads in the spleen and liver. MCMV infection led to >25-fold expansion of donor-spleen-derived MCMV-peptide-specific-tetramer+ CD8+ T-cells in blood of transplant recipients with and without cGvHD, but mice with cGvHD had far fewer antigen-specific T-cells in peripheral tissues and secondary lymphoid organs. The immuno-suppression associated with cGvHD was confirmed by vaccinating transplant recipients with and without cGvHD using a recombinant Listeria expressing MCMV early protein (Lm-MCMV). Secondary adoptive transfer of lymphocytes from donor mice with or without cGvHD into lymphopenic congenic recipients showed that cGvHD impaired tissue-specific homing of antigen specific T-cells. These results indicate cGvHD causes an intrinsic immuno-suppression and explain, in part, the functional immunodeficiency in allogeneic transplant recipients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Janin, H. Murata, C. Leboeuf, J.-M. Cayuela, E. Gluckman, L. Legres, A. Desveaux, M. Varna, P. Ratajczak, J. Soulier, et al. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation Blood, February 19, 2009; 113(8): 1834 - 1840. [Abstract] [Full Text] [PDF] M. S. Hossain, J. D. Roback, F. Wang, and E. K. Waller Host and Donor Immune Responses Contribute to Antiviral Effects of Amotosalen-Treated Donor Lymphocytes following Early Posttransplant Cytomegalovirus Infection J. Immunol., May 15, 2008; 180(10): 6892 - 6902. [Abstract] [Full Text] [PDF]

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