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Blood, 15 April 2007, Vol. 109, No. 8, pp. 3325-3332. Prepublished online as a Blood First Edition Paper on December 19, 2006; DOI 10.1182/blood-2006-04-017863. This Article Full Text (PDF) All Versions of this Article: blood-2006-04-017863v1 109/8/3325    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Woetmann, A. Articles by Odum, N. Search for Related Content PubMed PubMed Citation Articles by Woetmann, A. Articles by Odum, N. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 18, 2006 Accepted December 5, 2006 Non-malignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins Anders Woetmann, Paola Lovato, Karsten W Eriksen, Thorbjorn Krejsgaard, Tord Labuda, Qian Zhang, Anne-Merethe Mathiesen, Carsten Geisler, Arne Svejgaard, Mariusz A Wasik, and Niels Odum* IMB, University of Copenhagen, Copenhagen, Denmark Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States IMMI, University of Copenhagen, Copenhagen, Denmark Department of Clinical Immunology, University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark * Corresponding author; email: n.odum{at}immi.ku.dk. Bacterial toxins including staphylococcal enterotoxins (SE) have been implicated in the pathogenesis of cutaneous T cell lymphomas (CTCL). Here, we investigate SE-mediated interactions between non-malignant T cells and malignant T-cell lines established from skin and blood of CTCL patients. The malignant CTCL cells express MHC class II molecules which are high- affinity receptors for SE. Although treatment with SE has no direct effect on the growth of the malignant CTCL cells, the SE- treated CTCL cells induce vigorous proliferation of the SE-responsive non-malignant T cells. In turn, the non-malignant T cells enhance proliferation of the malignant cells in the SE- and MHC II-dependant manner. Furthermore, SE- and, in addition, alloantigen- presentation by malignant CTCL cells to irradiated non-malignant CD4+ T cell lines also enhances proliferation of the malignant cells. The growth-promoting effect depends on direct cell-cell contact and soluble factors such as interleukin-2. In conclusion, we demonstrate that SE triggers a bi-directional cross-talk between non-malignant T cells and malignant CTCL cells that promotes growth of the malignant cells. This represents a novel mechanism by which infections with SE- producing bacteria may contribute to pathogenesis of CTCL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Krejsgaard, C. S. Vetter-Kauczok, A. Woetmann, H. Kneitz, K. W. Eriksen, P. Lovato, Q. Zhang, M. A. Wasik, C. Geisler, E. Ralfkiaer, et al. Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma Blood, June 4, 2009; 113(23): 5896 - 5904. [Abstract] [Full Text] [PDF]

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