|
|
Blood, 1 October 2006, Vol. 108, No. 7, pp. 2300-2306.
Prepublished online as a Blood First Edition Paper on June 8, 2006; DOI 10.1182/blood-2006-04-017947.
 Previous Article | Next Article 
Submitted April 18, 2006
Accepted May 24, 2006
Ontogeny, function and peripheral homeostasis of
regulatory T cells in the absence of Interleukin-7
Regis Peffault de Latour, Helene C Dujardin, Florence Mishellany, Odile Burlen-Defranoux, Julien Zuber, Rute Marques, James P. Di Santo, Ana Cumano, Paulo Vieira*, and Antonio Bandeira
U Dev Lym/ Pasteur Institute
Centre Jean-Perrin
Instituto Gulbenkian de Ciencia
U Cyt Dev Lym/ Pasteur Institute
U Dev Lym/ Institut Pasteur
* Corresponding author; email: pvieira{at}pasteur.fr.
Mice lacking Interleukin-7 (IL-7-/- mice) have no signs of
autoimmune disease, contrary to other models of
lymphopenia. We investigated whether the absence of
disease was due to the fact that IL-7 is dispensable for
the ontogeny, function and homeostasis of regulatory CD4+
T cells. We show here that the establishment of the
peripheral pool of FOXP3-expressing regulatory cells is
IL-7 independent, and the premature involution of the
thymus in IL-7-/- mice does not change the representation
of the CD4+CD25+ T cell compartment. In addition,
CD4+CD25+ T cells expand in the absence of IL-7, without
losing FOXP3 expression. The frequency of activated
peripheral CD4+ T cells increases with age in both the
CD25- and CD25+ compartments, with the CD4+CD25+ T cells
displaying signs of constant activation. IL-7-/- CD4+CD25+
T cells control Inflammatory Bowel Disease induced by
IL-7-/- T cells even in hosts lacking IL-7. Depletion of
the CD25+ T cell subset after thymic involution, results
in a mild form of IBD, which resolves concomitantly with
the regeneration of this subset. This study shows for the
first time that IL-7-/- mice have a robust regulatory
FOXP3-expressing CD4+ T cell compartment that controls
T-cell mediated disease. It also highlights the potential
of the regulatory FOXP3-expressing CD4+CD25- T cell
population to restore a functional CD4+CD25+ T cell
compartment through an IL-7 independent pathway.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. L. Bayer, J. Y. Lee, A. de la Barrera, C. D. Surh, and T. R. Malek
A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells
J. Immunol.,
July 1, 2008;
181(1):
225 - 234.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Totsuka, T. Kanai, Y. Nemoto, S. Makita, R. Okamoto, K. Tsuchiya, and M. Watanabe
IL-7 Is Essential for the Development and the Persistence of Chronic Colitis
J. Immunol.,
April 15, 2007;
178(8):
4737 - 4748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. H. Nguyen, R. Zeiser, D. L. daSilva, D. S. Chang, A. Beilhack, C. H. Contag, and R. S. Negrin
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Blood,
March 15, 2007;
109(6):
2649 - 2656.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Lahl, C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease
J. Exp. Med.,
January 22, 2007;
204(1):
57 - 63.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
