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Blood, 1 February 2007, Vol. 109, No. 3, pp. 1322-1330. Prepublished online as a Blood First Edition Paper on October 12, 2006; DOI 10.1182/blood-2006-04-020172. This Article Full Text (PDF) All Versions of this Article: blood-2006-04-020172v1 109/3/1322    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Takahashi, S. Articles by Asano, S. Search for Related Content PubMed PubMed Citation Articles by Takahashi, S. Articles by Asano, S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 28, 2006 Accepted June 24, 2006 Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem cell transplantation from related donors in adult patients with hematological malignancies after myeloablative conditioning regimen Satoshi Takahashi*, Jun Ooi, Akira Tomonari, Takaaki Konuma, Nobuhiro Tsukada, Maki Oiwa-Monna, Kenji Fukuno, Michihiro Uchiyama, Kashiya Takasugi, Tohru Iseki, Arinobu Tojo, Takuhiro Yamaguchi, and Shigetaka Asano Institute of Medical Science, University of Tokyo, Japan School of Health Sciences and Nursing, University of Tokyo, Japan School of Science and Engineering, Waseda University, Japan * Corresponding author; email: radius{at}ims.u-tokyo.ac.jp. We studied the clinical outcomes of 171 adults with hematological malignancies who received unrelated cord blood transplantation (CBT) as a primary unrelated stem cell source (n=100), or bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT) from related donors (n=71, 55 BMT and 16 PBSCT). All patients received myeloablative regimens including 12 Gy of total body irradiation. We analyzed the hematological recovery, risks of graft-versus-host disease (GVHD), transplant-related mortality (TRM) and relapse, and disease-free survival (DFS) using Cox proportional hazards models. Significant delays in engraftment occurred after CBT; however, overall engraftment rates were almost the same for both grafts. The cumulative incidences of grades III to IV acute and extensive type chronic GVHDs among CBT recipients were significantly lower than those among BMT/PBSCT recipients. Multivariate analysis demonstrated no apparent differences in TRM (9% in CBT and 13% in BMT/PBSCT), relapse (17% in CBT and 26% in BMT/PBSCT) and DFS (70% in CBT and 60% in BMT/PBSCT) between both groups. These data suggest that unrelated cord blood could be as safe and effective a stem cell source as related bone marrow or mobilized peripheral blood for adult patients when it is used as a primary unrelated stem cell source. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. N. Barker Umbilical Cord Blood (UCB) Transplantation: An Alternative to the Use of Unrelated Volunteer Donors? Hematology, January 1, 2007; 2007(1): 55 - 61. [Abstract] [Full Text] [PDF] H. M. Lazarus and S. Luger Which Patients with Adult Acute Lymphoblastic Leukemia Should Undergo a Hematopoietic Stem Cell Transplantation? Case-Based Discussion Hematology, January 1, 2007; 2007(1): 444 - 452. [Abstract] [Full Text] [PDF]

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